A Man with Adenocarcinoma of the Rectum Rectal adenocarcinoma associated with the Lynch syndrome (hereditary nonpolyposis colorectal cancer), due to an MSH6 mutation

被引:0
|
作者
Blaszkowsky, Lawrence S. [1 ,7 ]
Cusack, James C., Jr. [2 ,8 ]
Hong, Theodore S. [4 ,9 ]
Chung, Daniel C. [3 ]
Blake, Michael A. [5 ,10 ]
Lennerz, Jochen K. [6 ,11 ]
机构
[1] Massachusetts Gen Hosp, Div Hematol Oncol, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Div Surg Oncol, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA
[6] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
[7] Harvard Univ, Sch Med, Dept Med, Boston, MA USA
[8] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA
[9] Harvard Univ, Sch Med, Dept Radiat Oncol, Boston, MA 02115 USA
[10] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA
[11] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
来源
NEW ENGLAND JOURNAL OF MEDICINE | 2011年 / 364卷 / 17期
关键词
TOTAL MESORECTAL EXCISION; PREOPERATIVE RADIOTHERAPY; POSTOPERATIVE CHEMORADIOTHERAPY; MICROSATELLITE INSTABILITY; LOCAL RECURRENCE; COLON-CANCER; PREDISPOSITION; FLUOROURACIL; CHEMOTHERAPY; LEUCOVORIN;
D O I
10.1056/NEJMcpc1011321
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1658 / 1668
页数:11
相关论文
共 50 条
  • [41] Incidence of hereditary nonpolyposis colorectal carcinoma-related cancer in clinically ascertained MLH1, MSH2 and MSH6 families
    Ramsoekh, D.
    van Leerdam, M. E.
    Wagner, A.
    Dooijes, D.
    Tops, C.
    Kuipers, E. J.
    [J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2008, 20 (07) : A26 - A27
  • [42] Two Cases of Germline EPCAM Mutation(s) as a Rare Cause of Hereditary Colorectal Adenocarcinoma (Lynch Syndrome)
    Patel, K.
    Arora, N.
    Pall, B.
    Gupta, P.
    Thamtam, V. K.
    Dey, D.
    Roy, P.
    Parihar, M.
    Mallath, M.
    Chawla, T.
    Roy, M.
    Ganguly, S.
    Mannan, A.
    Mishra, D. K.
    [J]. JOURNAL OF MOLECULAR DIAGNOSTICS, 2020, 22 (05): : S20 - S20
  • [43] Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients
    Hampel, Heather
    Frankel, Wendy
    Panescu, Jenny
    Lockman, Janet
    Sotamaa, Kaisa
    Fix, Daniel
    Comeras, Ilene
    La Jeunesse, Jennifer
    Nakagawa, Hidewaki
    Westman, Judith A.
    Prior, Thomas W.
    Clendenning, Mark
    Penzone, Pamela
    Lombardi, Janet
    Dunn, Patti
    Cohn, David E.
    Copeland, Larry
    Eaton, Lynne
    Fowler, Jeffrey
    Lewandowski, George
    Vaccarello, Luis
    Bell, Jeffrey
    Reid, Gary
    de la Chapelle, Albert
    [J]. CANCER RESEARCH, 2006, 66 (15) : 7810 - 7817
  • [44] Enteroscopic identification of an adenocarcinoma of the small bowel in a patient with previously unrecognized hereditary nonpolyposis colorectal cancer syndrome
    Pennazio, M
    Arrigoni, A
    Rossini, FP
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 1999, 94 (07): : 1962 - 1966
  • [45] Heterogeneous MSH6 Loss Is a Result of Microsatellite Instability within MSH6 and Occurs in Sporadic and Hereditary Colorectal and Endometrial Cancer
    Graham, R. P.
    Kerr, S. E.
    Butz, M.
    Thibodeau, S. N.
    Halling, K. C.
    Smyrk, T. C.
    Dina, M.
    Waugh, V.
    Rumilla, K.
    [J]. JOURNAL OF MOLECULAR DIAGNOSTICS, 2014, 16 (06): : 751 - 751
  • [46] Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome)
    Watson, P
    Ashwathnarayan, R
    Lynch, HT
    Roy, HK
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (22) : 2429 - 2431
  • [47] Characterization of colorectal cancer (CRC) in Lynch syndrome (LS) patients with MSH6 or PMS2 mutations
    Lee, Jean Kyung
    Shia, Jinru
    Rau-Murthy, Rohini
    Corines, Marina
    Salo-Mullen, Erin E.
    Markowitz, Arnold
    Robson, Mark E.
    Offit, Kenneth
    Guillem, Jose G.
    Saltz, Leonard
    Stadler, Zsofia Kinga
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
  • [48] MSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancer
    Bente A Talseth-Palmer
    Mary McPhillips
    Claire Groombridge
    Allan Spigelman
    Rodney J Scott
    [J]. Hereditary Cancer in Clinical Practice, 8
  • [49] MSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancer
    Talseth-Palmer, Bente A.
    McPhillips, Mary
    Groombridge, Claire
    Spigelman, Allan
    Scott, Rodney J.
    [J]. HEREDITARY CANCER IN CLINICAL PRACTICE, 2010, 8
  • [50] COLORECTAL CANCER IN MSH6 AND PMS2 LYNCH SYNDROME PATIENTS: CLINICAL PHENOTYPE IN A US POPULATION
    Guivatchian, Tannaz
    Rifkin, Samara
    Greve, Veronica
    Martinez, Julia
    Koeppe, Erika
    Stoffel, Elena M.
    [J]. GASTROENTEROLOGY, 2023, 164 (06) : S775 - S775