Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension glaucoma

被引：0

作者：

Suzuki, Misa ^{[1
]}

Meguro, Akira ^{[1
]}

Ota, Masao ^{[2
]}

Nomura, Eiichi ^{[1
]}

Kato, Tetsuo ^{[1
]}

Nomura, Naoko ^{[1
]}

Kashiwagi, Kenji ^{[3
]}

Mabuchi, Fumihiko ^{[3
]}

Iijima, Hiroyuki ^{[3
]}

Kawase, Kazuhide ^{[4
]}

Yamamoto, Tetsuya ^{[4
]}

Nakamura, Makoto ^{[5
]}

Negi, Akira ^{[5
]}

Sagara, Takeshi ^{[6
]}

Nishida, Teruo ^{[6
]}

Inatani, Masaru ^{[7
]}

Tanihara, Hidenobu ^{[7
]}

Aihara, Makoto ^{[8
]}

Araie, Makoto ^{[8
]}

Fukuchi, Takeo ^{[9
]}

Abe, Haruki ^{[9
]}

Higashide, Tomomi ^{[10
]}

Sugiyama, Kazuhisa ^{[10
]}

Kanamoto, Takashi ^{[11
]}

Kiuchi, Yoshiaki ^{[11
]}

Iwase, Aiko ^{[12
]}

Ohno, Shigeaki ^{[13
]}

Inoko, Hidetoshi ^{[14
]}

Mizuki, Nobuhisa ^{[1
]}

机构：

[1] Yokohama City Univ, Dept Ophthalmol & Visual Sci, Grad Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan

[2] Shinshu Univ, Sch Med, Dept Legal Med, Nagano, Japan

[3] Univ Yamanashi, Fac Med, Dept Ophthalmol, Yamanashi, Japan

[4] Gifu Univ, Dept Ophthalmol, Grad Sch Med, Gifu, Japan

[5] Kobe Univ, Grad Sch Med, Div Ophthalmol, Dept Surg, Kobe, Hyogo 657, Japan

[6] Yamaguchi Univ, Sch Med, Dept Biomol Recognit & Ophthalmol, Yamaguchi, Japan

[7] Kumamoto Univ, Dept Ophthalmol & Visual Sci, Grad Sch Med Sci, Kumamoto, Japan

[8] Univ Tokyo, Sch Med, Dept Ophthalmol, Tokyo 113, Japan

[9] Niigata Univ, Graduated Sch Med & Dent Sci, Div Ophthalmol & Visual Sci, Niigata, Japan

[10] Kanagawa Univ, Grad Sch Med Sci, Dept Ophthalmol & Visual Sci, Kanazawa, Ishikawa, Japan

[11] Hiroshima Univ, Grad Sch Biomed Sci, Dept Ophthalmol & Visual Sci, Hiroshima, Japan

[12] Tajimi Municipal Hosp, Dept Ophthalmol, Gifu, Japan

[13] Hokkaido Univ, Grad Sch Med, Dept Ophthalmol, Sapporo, Hokkaido, Japan

[14] Tokai Univ, Sch Med, Div Mol Life Sci, Dept Genet Informat, Kanagawa 2591100, Japan

来源：

MOLECULAR VISION | 2010年 / 16卷 / 203期

关键词：

OPEN-ANGLE GLAUCOMA; HISTOCOMPATIBILITY ANTIGENS; OCULAR HYPERTENSION; SERUM AUTOANTIBODY; HLA ANTIGENS; RISK-FACTORS; ASSOCIATION; PROGRESSION; PREVALENCE; ANTIBODIES;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose: Normal tension glaucoma (NTG) is a subtype of glaucoma in which intraocular pressure is within the statistically normal range. NTG may be associated with an immune disorder. The aim of this study was to determine whether specific alleles in the human leukocyte antigen (HLA)-DRB1 and HLA-DQB1 genes correlated with NTG in Japanese patients. Methods: We genotyped the HLA-DRB1 and HLA-DQB1 alleles in 113 Japanese patients with NTG and in 184 healthy Japanese control subjects using the polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) Luminex method. We assessed the allelic diversity in patients and controls. Results: There were no statistically significant differences in the allele frequency of HLADRB1 and HLA-DQB1 between NTG patients and control subjects, and no HLA-DRB1-HLA-DQB1 haplotypes demonstrated any significant association with NTG. Conclusions: Our findings suggest that HLA-DRB1 and HLA-DQB1 polymorphisms have no significant effect on the development of NTG in Japanese patients.

引用

页码：1874 / 1879

页数：6

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