RETRACTED: Lithium in the treatment of neutropenia (Retracted article. See vol. 19, pg. 241, 2012)

被引：23

作者：

Petrini, Mario ^{[1
]}

Azzara, Antonio ^{[1
]}

机构：

[1] Univ Pisa AOUP, Unit Haematol, Dept Oncol Transplants & Adv Technol Med, Pisa, Italy

来源：

CURRENT OPINION IN HEMATOLOGY | 2012年 / 19卷 / 01期

关键词：

CD34; engraftment; neutropenia; stem cell mobilization; stem cell transplantation; SHWACHMAN-DIAMOND-SYNDROME; CLOZAPINE-INDUCED NEUTROPENIA; CANINE CYCLIC HEMATOPOIESIS; COLONY-STIMULATING ACTIVITY; FELTYS-SYNDROME; STEM-CELLS; INDUCED GRANULOCYTOSIS; LEUKOCYTE CHEMOTAXIS; CARBONATE THERAPY; RADIATION-INJURY;

D O I：

10.1097/MOH.0b013e32834da93b

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review The capacity of lithium to induce neutrophilia and increase circulating CD34(+) cells of marrow origin has long been known. Lithium has been the object of hematological investigations for many years, but no definitive use in hematology has yet emerged. Recent findings We review the evidence that lithium increases granulocyte colony-stimulating factor (G-CSF) and augments G-CSF effects, showing its potential use in stem cell mobilization and engraftment of stem cell transplantation. Summary We suggest possible therapeutic uses of lithium in neutropenia. In bone marrow transplantation, preharvest lithium-assisted hematopoietic stem cell mobilization may be useful as well.

引用

页码：52 / 57

页数：6

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