What does it take to bind CAR?

被引：47
|
作者：
Law, LK
Davidson, BL
机构：
[1] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA
[2] Univ Iowa, Program Gene Therapy, Iowa City, IA 52242 USA
[3] Univ Iowa, Genet PhD Program, Iowa City, IA 52242 USA
[4] Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA
[5] Univ Iowa, Dept Physiol & Biophys, Iowa City, IA 52242 USA
来源：
MOLECULAR THERAPY | 2005年 / 12卷 / 04期
基金：
美国国家卫生研究院;
关键词：
adenovirus; serotype; 30; fiber protein; crystal structure; CAR;
D O I：
10.1016/j.ymthe.2005.05.017
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Recombinant adenoviruses (Ads) have been used as reagents for biological studies and therapeutic protocols for the treatment of human patients. The two most commonly used Ads, Ad2 and Ads, infect a broad range of tissues through interaction with the coxsackie and adenovirus receptor CAR. Both mutational analyses and crystal structure data have established residues in the fiber knob and shaft critical for Ad-CAR binding. In this report we review the contributions of various residues to Ad-CAR binding, taking into consideration the documented cellular tropism of other Ad serotypes.
引用
收藏
页码：599 / 609
页数：11
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