The Application of Induced Pluripotent Stem Cells in Cardiac Disease Modeling and Drug Testing

被引：21
|
作者：
Ye, Lingqun [1 ,2 ]
Ni, Xuan [1 ,2 ]
Zhao, Zhen-Ao [1 ,2 ,3 ,4 ]
Lei, Wei [1 ,2 ,3 ,4 ]
Hu, Shijun [1 ,2 ,3 ,4 ]
机构：
[1] Soochow Univ, Coll Med, Affiliated Hosp 1, Inst Cardiovasc Sci, Suzhou 215000, Peoples R China
[2] Soochow Univ, Coll Med, Affiliated Hosp 1, Dept Cardiovasc Surg, Suzhou 215000, Peoples R China
[3] Key Lab Stem Cells & Biomed Mat Jiangsu Prov, Suzhou 215000, Peoples R China
[4] Chinese Minist Sci & Technol, Suzhou 215000, Peoples R China
来源：
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2018年 / 11卷 / 05期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Induced pluripotent stem cells; Cardiovascular diseases; Disease modeling; Drug testing; LONG-QT SYNDROME; IPSC-DERIVED CARDIOMYOCYTES; HYPERTROPHIC CARDIOMYOPATHY; DILATED CARDIOMYOPATHY; TISSUE; PHENOTYPE; HEART; RECAPITULATE; GENERATION; MATURATION;
D O I：
10.1007/s12265-018-9811-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent decades, cardiovascular diseases have become the greatest health threat to human beings, and thus it is particularly important to explore the subtle underlying pathogenesis of cardiovascular diseases. Although many molecular pathways have been explored to be essential in the development of cardiovascular diseases, their clinical significances are still uncertain. With the emergence of induced pluripotent stem cells (iPSCs), a unique platform for cardiovascular diseases has been established to model cardiovascular diseases on specific genetic background in vitro. This review summarizes current progresses of iPSCs in cardiovascular disease modeling and drug testing. This review highlighted iPSC-based cardiovascular disease modeling and drug testing. The technical advances in iPSC-based researches and various clinically relevant applications are discussed. With further intensive research, iPSC technology will shape the future of clinical translational research in cardiovascular diseases.
引用
收藏
页码：366 / 374
页数：9
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