Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain

被引:42
|
作者
Tüzün, F
Ünalan, H
Öner, N
Özgüzel, H
Kirazli, Y
Içagasioglu, A
Kuran, B
Tüzün, S
Basar, G
机构
[1] Istanbul Univ, Cerrahpasa Med Fac, Dept Phys Med & Rehabil, Istanbul, Turkey
[2] SSK Okmeydani Hosp, Div Phys Med & Rehabil, Istanbul, Turkey
[3] Ege Univ, Fac Med, Dept Phys Med & Rehabil, Izmir, Turkey
[4] SSK Goztepe Hosp, Div Phys Med & Rehabil, Istanbul, Turkey
[5] Sisli Etfal Hosp, Div Phys Med & Rehabil, Istanbul, Turkey
关键词
muscle relaxant; thiocolchicoside; low back pain;
D O I
10.1016/S1297-319X(03)00075-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. - To evaluate the efficacy of intramuscular injection of thiocolchicoside (4 mg-2 ml) compared to placebo administered twice daily for 5 days in patients suffering from acute low back pain. Patients and methods. - Multicenter, randomized, double-blinded, placebo-controlled trial. The study was conducted between July 1998 and March 2000 in five centers. Hospitalized patients with acute low back pain were included. The primary evaluation criterion was spontaneous pain at rest assessed by visual analog scale (VAS). Hand-to-floor distance, muscle spasm intensity, patients' global evaluation and analgesic tablet (paracetamol) consumption were used as secondary evaluation criteria. Results. - One hundred and forty nine patients were included. Both groups showed improvement on spontaneous pain assessed by VAS at the end of day 1; however, improvement was statistically significant in thiocolchicoside group on day 3 (P < 0.001). Hand-to-floor distance and muscle spasm determined by palpation decreased significantly on day 5 in thiocolchicoside group (P < 0.0005 for both). According to the patients' global evaluation, 76.8% of patients in thiocolchicoside group evaluated the treatment as very good/good (P < 0.0005). Also a significant difference was observed in favor of the thiocolchicoside group in the total paracetamol consumption (P < 0.001). Treatment was well tolerated in both groups and none of the patients was withdrawn from the study due to an adverse effect. Conclusion. - Twice daily administration of 4 mg thiocolchicoside for 5 days provides an efficient and safe treatment for patients with acute low back pain accompanied by muscle spasm. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:356 / 361
页数:6
相关论文
共 50 条
  • [21] Bupivacaine Use After Posterior Colporrhaphy to Reduce Postoperative Pain: A Multicenter, Double-Blinded, Placebo-Controlled, Randomized Clinical Trial
    Kaeser, Carson T.
    Rothenberger, Rodger
    Zoorob, Dani
    Whiteside, James L.
    FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY, 2022, 28 (02): : 72 - 76
  • [22] Dexamethasone on postoperative gastrointestinal motility: A placebo-controlled, double-blinded, randomized controlled trial
    Chen, Yuezhi
    Dong, Chenyang
    Lian, Guodong
    Li, Dongsheng
    Yin, Yuehan
    Yu, Wenhai
    Du, Changkun
    Liu, Chen
    Li, Leping
    Tian, Feng
    Jing, Changqing
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2020, 35 (09) : 1549 - 1554
  • [23] A Randomized, Double-Blinded, Placebo-Controlled Trial of Simvastatin to Prevent Recurrent Pancreatitis
    Goodman, Marc T.
    Lo, Simon K.
    Yadav, Dhiraj
    Wu, Bechien U.
    Jamil, Laith H.
    Kwok, Karl K.
    Papachristou, Georgios I.
    Afghani, Elham
    Choi-Kuaea, Yunhee
    Waldron, Richard T.
    Lombardi, Christina
    Jeon, Christie Y.
    Helenowski, Irene B.
    Richmond, Ellen
    Benante, Kelly
    Habtezion, Aida
    Schering, Tia
    Khan, Seema A.
    Rodriguez, Luz M.
    Pandol, Stephen J.
    PANCREAS, 2022, 51 (01) : e10 - e12
  • [24] Premedication with intravenous ketorolac in colonoscopy: A randomized double-blinded placebo-controlled trial
    Mui, WL
    Kwong, WH
    Li, A
    Ng, EK
    Yeung, AA
    Poon, CN
    Leong, HT
    GASTROINTESTINAL ENDOSCOPY, 2005, 61 (05) : AB81 - AB81
  • [25] Rifaximin for the Treatment of Functional Dyspepsia: A Double-Blinded Randomized Placebo-Controlled Trial
    Tan, Victoria P.
    Liu, Sze Hang Kevin
    Lam, Frank Y.
    Hung, Ivan F.
    Leung, Wai K.
    GASTROENTEROLOGY, 2015, 148 (04) : S49 - S49
  • [26] Synbiotics and Treatment of Asthma: A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial
    Hassanzad, Maryam
    Mostashari, Keyvan Maleki
    Ghaffaripour, Hosseinali
    Emami, Habib
    Limouei, Samane Rahimi
    Velayati, Ali Akbar
    GALEN MEDICAL JOURNAL, 2019, 8
  • [27] A randomized, placebo-controlled, double-blinded, crossover trial of pioglitazone for severe asthma
    Kaler, Maryann
    Barochia, Amisha V.
    Weir, Nargues A.
    Cuento, Rosemarie A.
    Stylianou, Mario
    Roth, Mark J.
    Filie, Armando C.
    Vaughey, Ellen C.
    Nathan, Steven D.
    Levine, Stewart J.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (06) : 1716 - 1718
  • [28] Propranolol for induction of labor in nulliparas: a double-blinded, randomized, placebo-controlled trial
    Bigelow, Catherine A.
    Pan, Stephanie
    Overbey, Jessica
    Stone, Joanne
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2020, 222 (01) : S26 - S27
  • [29] The effect of dry needling in the treatment of myofascial pain syndrome: a randomized double-blinded placebo-controlled trial
    Tekin, Levent
    Akarsu, Selim
    Durmus, Oguz
    Cakar, Engin
    Dincer, Umit
    Kiralp, Mehmet Zeki
    CLINICAL RHEUMATOLOGY, 2013, 32 (03) : 309 - 315
  • [30] Intravenous acetaminophen for postoperative supratentorial craniotomy pain: a prospective, randomized, double-blinded, placebo-controlled trial
    Sivakumar, Walavan
    Jensen, Michael
    Martinez, Julie
    Tanana, Michael
    Duncan, Nancy
    Hoesch, Robert
    Riva-Cambrin, Jay K.
    Kilburg, Craig
    Ansari, Safdar
    House, Paul A.
    JOURNAL OF NEUROSURGERY, 2019, 130 (03) : 766 - 772