Quinazolin-4(3H)-ones: A Tangible Synthesis Protocol via an Oxidative Olefin Bond Cleavage Using Metal-Catalyst Free Conditions

被引：7
|
作者：
Sharif, Muhammad [1 ]
机构：
[1] King Fand Univ Petr & Minerals, Dept Chem, Dhahran 31261, Saudi Arabia
来源：
APPLIED SCIENCES-BASEL | 2020年 / 10卷 / 08期
关键词：
catalysis; metal-free; catalyst-free; quinazolinone; styrene; o-Aminobenzamide; antioxidant; anticancer; ONE-POT SYNTHESIS; CARBONYLATIVE SYNTHESIS; O-AMINOBENZAMIDES; PRIMARY ALCOHOLS; BENZYL ALCOHOLS; QUINAZOLINONES; OZONOLYSIS; DERIVATIVES; CONVENIENT; BENZAMIDES;
D O I：
10.3390/app10082815
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and selective oxidative procedure for the synthesis of quinazolinones from readily available o-aminobenzamides and styrenes was developed. A number of potentially pharmacologically relevant quinazolinones were prepared using metal- and catalyst-free conditions. The synthesis procedure highlights the sustainable operation, low-priced, free from perilous materials, green solvent and environmental affability. The synthesized products were isolated in moderate to excellent yields.
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页数：11
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