Quinazolin-4(3H)-ones: A Tangible Synthesis Protocol via an Oxidative Olefin Bond Cleavage Using Metal-Catalyst Free Conditions

被引：7
|
作者：
Sharif, Muhammad [1 ]
机构：
[1] King Fand Univ Petr & Minerals, Dept Chem, Dhahran 31261, Saudi Arabia
来源：
APPLIED SCIENCES-BASEL | 2020年 / 10卷 / 08期
关键词：
catalysis; metal-free; catalyst-free; quinazolinone; styrene; o-Aminobenzamide; antioxidant; anticancer; ONE-POT SYNTHESIS; CARBONYLATIVE SYNTHESIS; O-AMINOBENZAMIDES; PRIMARY ALCOHOLS; BENZYL ALCOHOLS; QUINAZOLINONES; OZONOLYSIS; DERIVATIVES; CONVENIENT; BENZAMIDES;
D O I：
10.3390/app10082815
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and selective oxidative procedure for the synthesis of quinazolinones from readily available o-aminobenzamides and styrenes was developed. A number of potentially pharmacologically relevant quinazolinones were prepared using metal- and catalyst-free conditions. The synthesis procedure highlights the sustainable operation, low-priced, free from perilous materials, green solvent and environmental affability. The synthesized products were isolated in moderate to excellent yields.
引用
收藏
页数：11
相关论文
共 50 条
  • [1] Synthesis of Quinazolin-4(3H)-ones via a novel approach
    Akbari, Ali
    Zahedifar, Mahboobeh
    JOURNAL OF SAUDI CHEMICAL SOCIETY, 2023, 27 (02)
  • [2] SYNTHESIS OF ISOXAZOLYL QUINAZOLIN-4 (3H)-ONES
    Rajanarendar, E.
    Venkateshwarlu, P.
    Ramakrishna, S.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2012, 22 (02) : 95 - 98
  • [3] Ecofriendly synthesis of quinazolin-4(3H)-ones
    Kidwai, M
    Rastogi, R
    Rastogi, S
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2004, 43 (02): : 423 - 425
  • [4] Synthesis of quinazolin-4(3H)-ones, an update
    Picos-Corrales, Lorenzo A.
    Sarmiento-Sanchez, Juan I.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2018, 54 (08) : 762 - 764
  • [5] A Metal- and Ligand-Free Synthesis of Quinazolin-4(3H)-ones via a Bu4NI/TBHP-Mediated Oxidative Cleavage of the Olefinic C=C Bond
    Karasala, B. K.
    Gollamudi, P.
    Inkollu, B.
    Vidavalur, S.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 56 (08) : 1446 - 1454
  • [6] A Metal- and Ligand-Free Synthesis of Quinazolin-4(3H)-ones via a Bu4NI/TBHP-Mediated Oxidative Cleavage of the Olefinic C=C Bond
    B. K. Karasala
    P. Gollamudi
    B. Inkollu
    S. Vidavalur
    Russian Journal of Organic Chemistry, 2020, 56 : 1446 - 1454
  • [7] SYNTHESIS OF BENZOXAZOLYLTHIOMETHYL AND BENZTHIAZOLYLTHIOMETHYL QUINAZOLIN-4(3H)-ONES
    Rafeeq, Mohammad
    Reddy, Chittireddy Venkata Ramana
    Dubey, Pramod Kumar
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2015, 190 (11) : 1857 - 1864
  • [8] Synthesis of Quinazolin-4(3H)-ones via Amidine N-Arylation
    Li, Bryan
    Samp, Lacey
    Sagal, John
    Hayward, Cheryl M.
    Yang, Christine
    Zhang, Zhijun
    JOURNAL OF ORGANIC CHEMISTRY, 2013, 78 (03): : 1273 - 1277
  • [9] Synthesis of substituted quinazolin-4(3H)-ones and quinazolines via directed lithiation
    El-Hiti, GA
    HETEROCYCLES, 2000, 53 (08) : 1839 - +
  • [10] A convenient synthesis of substituted quinazolin-4(3H)-ones under microwave and solvent-free conditions
    Montazeri, N
    Rad-Moghadam, K
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2004, 179 (12) : 2533 - 2536
12345