Endothelial-stromal interactions in angiogenesis

被引:125
|
作者
Hughes, Christopher C. W. [1 ]
机构
[1] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA
关键词
angiogenesis; endothelial; extracellular matrix; myofibroblast; pericyte; tumor stroma;
D O I
10.1097/MOH.0b013e3282f97dbc
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Angiogenesis often occurs in the context of a wound or tumor stroma. This review will on the recent findings on the interactions between angiogenic endothelial cells the other components of the stroma-fibroblasts, pericytes and extracellular matrix. Recent findings Large-scale gene expression arrays have provided a remarkable insight into the diversity of fibroblasts in different tissues and under different conditions. These somewhat neglected cells are now understood to play a critical role in tumor growth, regulating not only the phenotype of the tumor cells but also the angiogenic response that supports them. These advances are leading to an understanding of the soil and seed hypothesis at the molecular level. In addition, there is a new focus on the role of pericytes in regulating angiogenesis and their potential as targets for tumor therapy. Summary Initiation of new blood vessel formation requires metalloproteinases induction leading to the degradation of the basement membrane, sprouting of endothelial cells and regulation of pericyte attachment. Fibroblasts and their activated counterpart, the myofibroblast, play a large role in synchronizing these events through the expression of numerous extracellular matrix molecules, growth factors and morphogens, including fibroblast growth factors and transforming growth factor beta.
引用
收藏
页码:204 / 209
页数:6
相关论文
共 50 条
  • [31] Fibroblast growth factor 2 activation of stromal cell vascular endothelial growth factor expression and angiogenesis
    Claffey, KP
    Abrams, K
    Shih, SC
    Brown, LF
    Mullen, A
    Keough, M
    LABORATORY INVESTIGATION, 2001, 81 (01) : 61 - 75
  • [32] Collagen modules for in situ delivery of mesenchymal stromal cell-derived endothelial cells for improved angiogenesis
    Portalska, Karolina Janeczek
    Chamberlain, M. Dean
    Lo, Chuen
    van Blitterswijk, Clemens
    Sefton, Michael V.
    de Boer, Jan
    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2016, 10 (05) : 363 - 373
  • [33] Endothelial cells and angiogenesis
    Sepp, N
    Fritsch, P
    Luger, TA
    EXPERIMENTAL DERMATOLOGY, 1997, 6 (05) : 272 - 273
  • [34] Stromal angiogenesis in human glioma: A role of platelet-derived endothelial cell growth factor - Commentary
    Shapiro, WR
    SURGICAL NEUROLOGY, 1998, 49 (02): : 187 - 188
  • [35] A three-dimensional model with two-body interactions for endothelial cells in angiogenesis
    Sakai, Kazuma
    Hayashi, Tatsuya
    Sakai, Yusuke
    Mada, Jun
    Tonami, Kazuo
    Uchijima, Yasunobu
    Kurihara, Hiroki
    Tokihiro, Tetsuji
    SCIENTIFIC REPORTS, 2023, 13 (01):
  • [36] A three-dimensional model with two-body interactions for endothelial cells in angiogenesis
    Kazuma Sakai
    Tatsuya Hayashi
    Yusuke Sakai
    Jun Mada
    Kazuo Tonami
    Yasunobu Uchijima
    Hiroki Kurihara
    Tetsuji Tokihiro
    Scientific Reports, 13 (1)
  • [37] Reciprocal paracrine interactions between tumour cells and endothelial cells: The 'Angiogenesis progression' hypothesis
    Rak, J
    Filmus, J
    Kerbel, RS
    EUROPEAN JOURNAL OF CANCER, 1996, 32A (14) : 2438 - 2450
  • [38] Sprouting Angiogenesis under a Chemical Gradient Regulated by Interactions with an Endothelial Monolayer in a Microfluidic Platform
    Jeong, Gi Seok
    Han, Sewoon
    Shin, Yoojin
    Kwon, Gu Han
    Kamm, Roger D.
    Lee, Sang-Hoon
    Chung, Seok
    ANALYTICAL CHEMISTRY, 2011, 83 (22) : 8454 - 8459
  • [39] Untangling kinase-based signalling interactions in endothelial cell migration and angiogenesis.
    Hsiao, Y.
    Tsai, C.
    Lin, H.
    Yu, L.
    Tsai, F.
    MOLECULAR BIOLOGY OF THE CELL, 2017, 28
  • [40] Agent Based Model of Endothelial Cell and Pericyte Interactions During Angiogenesis in the Germinal Matrix
    Rikard, Michaela
    Patolia, Harsh
    Chappell, John
    Peirce, Shayn M.
    FASEB JOURNAL, 2018, 32 (01):