Suppressive effect of SATB1 on hepatic stellate cell activation and liver fibrosis in rats

被引：15
|
作者：
He, Jiayi [1 ]
Gong, Jin [1 ]
Ding, Qiang [1 ]
Tan, Qinghai [1 ]
Han, Ping [1 ]
Liu, Jingmei [1 ]
Zhou, Zhenzhen [1 ]
Tu, Wei [1 ]
Xia, Yujia [1 ]
Yan, Wei [1 ]
Tian, Dean [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan 430074, Peoples R China
来源：
FEBS LETTERS | 2015年 / 589卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Liver fibrosis; Hepatic stellate cell; SATB1; Ras/Raf-1/MEK/ERK/Ets-1; TISSUE GROWTH-FACTOR; PROMOTER ACTIVITY; MULTIPLE GENES; TUMOR-GROWTH; TGF-BETA; EXPRESSION; PROTEIN; BINDING; CANCER; METASTASIS;
D O I：
10.1016/j.febslet.2015.04.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Liver fibrosis is a worldwide clinical issue. Activation of hepatic stellate cells (HSCs) is the central event during liver fibrosis. We investigated the role of SATB1 in HSC activation and liver fibrogenesis. The results show that SATB1 expression is reduced during HSC activation. Additionally, SATB1 inhibits HSC activation, proliferation, migration, and collagen synthesis. Furthermore, CTGF, a pro-fibrotic agent, is also significantly inhibited by SATB1 through the Ras/Raf-1/MEK/ERK/Ets-1 pathway. In vivo, SATB1 deactivates HSCs and attenuates fibrosis in TAA-induced fibrotic rat livers. These data indicate that SATB1 plays an important role in HSC activation and liver fibrosis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1359 / 1368
页数：10
相关论文
共 50 条
  • [21] CRITICAL ROLE FOR ACID SPHINGOMYELINASE IN HEPATIC STELLATE CELL ACTIVATION AND LIVER FIBROSIS
    Jimenez-Rojo, Noemi
    Goni, Felix M.
    Alonso, Alicia
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2010, 382 : 19 - 19
  • [22] Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis
    Xue-Ke Zhao
    Lei Yu
    Ming-Liang Cheng
    Pulin Che
    Yin-Ying Lu
    Quan Zhang
    Mao Mu
    Hong Li
    Li-Li Zhu
    Juan-Juan Zhu
    Meng Hu
    Po Li
    Yue-Dong Liang
    Xin-Hua Luo
    Yi-Ju Cheng
    Zhi-Xiang Xu
    Qiang Ding
    Scientific Reports, 7
  • [23] Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosis
    Kohji Otogawa
    Tomohiro Ogawa
    Ryoko Shiga
    Kazuo Ikeda
    Norifumi Kawada
    Hepatology International, 2009, 3
  • [24] Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis
    Barcena-Varela, Marina
    Colyn, Leticia
    Fernandez-Barrena, Maite G.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (10)
  • [25] Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis
    Zhao, Xue-Ke
    Yu, Lei
    Cheng, Ming-Liang
    Che, Pulin
    Lu, Yin-Ying
    Zhang, Quan
    Mu, Mao
    Li, Hong
    Zhu, Li-Li
    Zhu, Juan-Juan
    Hu, Meng
    Li, Po
    Liang, Yue-Dong
    Luo, Xin-Hua
    Cheng, Yi-Ju
    Xu, Zhi-Xiang
    Ding, Qiang
    SCIENTIFIC REPORTS, 2017, 7
  • [26] ACID SPHINGOMYELINASE CONTROLS HEPATIC STELLATE CELL ACTIVATION AND IN VIVO LIVER FIBROSIS
    Moles, A.
    Tarrats, N.
    Morales, A.
    Dominguez, M.
    Bataller, R.
    Caballeria, J.
    Garcia-Ruiz, C.
    Fernandez-Checa, J. C.
    Mari, M.
    JOURNAL OF HEPATOLOGY, 2010, 52 : S373 - S373
  • [27] Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosis
    Otogawa, Kohji
    Ogawa, Tomohiro
    Shiga, Ryoko
    Ikeda, Kazuo
    Kawada, Norifumi
    HEPATOLOGY INTERNATIONAL, 2009, 3 (02) : 378 - 383
  • [28] The inductor of interferonogenesis amiksin in reducing of liver fibrosis and Hepatic Stellate Cell activation
    Abdulchakov, S
    Sozinov, A
    Kiassov, A
    JOURNAL OF HEPATOLOGY, 2002, 36 : 67 - 68
  • [29] Human antigen R contributes to hepatic stellate cell activation and liver fibrosis
    Woodhoo, Ashwin
    Iruarrizaga-Lejarreta, Marta
    Beraza, Naiara
    Garcia-Rodriguez, Juan L.
    Embade, Nieves
    Fernandez-Ramos, David
    Martinez-Lopez, Nuria
    Gutierrez-De Juan, Virginia
    Arteta, Beatriz
    Caballeria, Juan
    Lu, Shelly C.
    Mato, Jose M.
    Varela-Rey, Marta
    Martinez-Chantar, Maria L.
    HEPATOLOGY, 2012, 56 (05) : 1870 - 1882
  • [30] Inhibition of Hepatic Stellate Cell Activation and Liver Fibrosis by Expression of Cytoglobin In Vivo
    Xu, Ruian
    Harrison, Phillip
    Li, Xinyan
    Chen, Miao
    Li, Hua
    Cheung, Pik-to
    Xiao, Weidong
    Farzaneh, Farzin
    MOLECULAR THERAPY, 2006, 13 : S171 - S172
12345