Solubilization of celecoxib, lamotrigine and phenytoin using ethanol and a nonionic surfactant

被引：7

作者：

Jouyban-Gharamaleki, Vahid ^{[1
,2
]}

Soleymani, Jafar ^{[3
]}

Jouyban-Gharamaleki, Karim ^{[4
]}

Suleymanov, Tahir A. ^{[5
]}

Jouyban, Abolghasem ^{[6
,7
]}

机构：

[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan KIPA Sci Based Co, Tabriz, Iran

[3] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran

[4] Tabriz Univ Med Sci, Food & Drug Safety Res Ctr, Tabriz, Iran

[5] Azerbaijan Med Univ, Fac Pharm, Dept Pharmaceut Chem, Baku, Azerbaijan

[6] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[7] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2017年 / 243卷

关键词：

Lamotrigine; Phenytoin; Celecoxib; Tween; 80; Jouyban-Acree model; Micellar effect; Cosolvency; WATER-SOLUBLE DRUGS; METHANOL+1-PROPANOL MIXTURES; PROPYLENE-GLYCOL; TWEEN; 80; TEMPERATURES; TRIS(HYDROXYMETHYL)AMINOMETHANE; FORMULATION; DISCOVERY; MODELS; SYSTEM;

D O I：

10.1016/j.molliq.2017.08.080

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Using micellar medium as a solubilization technique is an influential approach for solubilization of drugs with high hydrophobicity. It may be combined with cosolvency to provide more solubility. This work reports the effects of Tween 80 as a nonionic surfactant and ethanol as a commonly used cosolvent on the solubilities of celecoxib, phenytoin and lamotrigine at 298.2 K. As experimental results approved the effect of Tween 80 on the solubility of celecoxib is more than the others. The experimental data points were fitted to the Jouyban-Acree, general single and modified Wilson models and then back-calculated solubilities were calculated where the mean percentage deviations were 9.7%, 133% and 14.0%, respectively. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：715 / 719

页数：5

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