Cerium(III) chloride:: A highly efficient reagent for the synthesis of α-aminonitriles

被引：28

作者：

Pasha, M. A. ^{[1
]}

Nanjundaswamy, H. M. ^{[2
]}

Jayashankara, V. P. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Studies Chem, Bangalore 560001, Karnataka, India

[2] Inst Publ Hlth, Chem Examinat Sect, Bangalore, Karnataka, India

来源：

SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 22-24期

关键词：

amines; alpha-aminonitriles; carbonyl compounds; cerium(III) chloride; one-pot three-component condensation;

D O I：

10.1080/00397910701578180

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a highly efficient, one-pot, three-component condensation of carboryl compounds, amines, and TMSCN in MeCN; the reaction is significantly promoted by the catalytic amount of cerium(III) chloride at ambient temperature in excellent yields without any adverse effect on the other substituents. The method afforded an elegant alternative to the synthesis of alpha-aminonitriles. The reactions are fast and clean, and the products obtained are of high purity.

引用

页码：4371 / 4380

页数：10

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