Immune-mediated Neuropathy with Epstein-Barr virus-positive T-cell Lymphoproliferative Disease

被引：0
|
作者：
Hattori, Takaaki [1 ]
Arai, Ayako [2 ]
Yokota, Takanori [1 ]
Imadome, Ken-Ichi [3 ]
Tomimitsu, Hiroyuki [1 ]
Miura, Osamu [2 ]
Mizusawa, Hidehiro [1 ]
机构：
[1] Tokyo Med & Dent Univ, Grad Sch, Dept Neurol & Neurol Sci, Tokyo, Japan
[2] Tokyo Med & Dent Univ, Dept Hematol, Tokyo, Japan
[3] Natl Res Inst Child Hlth & Dev, Dept Infect Dis, Tokyo, Japan
来源：
INTERNAL MEDICINE | 2015年 / 54卷 / 01期
基金：
日本学术振兴会;
关键词：
neuropathy; EBV-T/NK-LPD; CAEBV; immune-mediated; Guillain-Barre syndrome; INFECTION; TRANSPLANTATION; GUIDELINES;
D O I：
10.2169/internalmedicine.54.3173
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 47-year-old man with Epstein-Barr virus (EBV)-positive T/NK-cell lymphoproliferative disease (EBVT/NK-LPD) developed acute-onset weakness. A nerve conduction study showed a conduction block in both the proximal and most distal segments. Although the patient's neuropathy transiently responded to intravenous immunoglobulin, it was progressive for at least 25 days until the start of prednisolone (PSL) administration, after which it remarkably improved. The neuropathy further improved after allogeneic bone marrow transplantation (BMT). The present patient's clinical course is not consistent with that of typical Guillain-Barre syndrome. This case suggests that EBV-T/NK-LPD can cause progressive immune-mediated neuropathy as a result of chronic EBV antigen presentation and can be treated with PSL and BMT.
引用
收藏
页码：69 / 73
页数：5
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