Application of (lamellar) keratoplasty and limbal stem cell transplantation for corneal clouding in the mucopolysaccharidoses - a review

被引:9
|
作者
Pinello, Luisa [4 ]
Busin, Massimo [3 ]
Fontana, Luigi [2 ]
Dua, Harminder S. [1 ]
机构
[1] Univ Nottingham, Div Ophthalmol & Visual Sci, Nottingham NG7 2UH, England
[2] Unita Operat Oculist, Bologna, Italy
[3] Villa Serena Hosp, Dept Ophthalmol, Forli, Italy
[4] Univ Padua, Dept Paediat, Paediatr Low Vis Ctr Veneto Reg, I-35100 Padua, Italy
来源
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2010年 / 38卷
关键词
corneal disease; corneal transplantation; limbus corneae; mucopolysaccharidosis; stem cell transplantation; MAROTEAUX-LAMY-SYNDROME; BIG-BUBBLE TECHNIQUE; EPITHELIAL MAINTENANCE; DESCEMETS-MEMBRANE; OCULAR SURFACE; SYSTEMIC MUCOPOLYSACCHARIDOSIS; PENETRATING KERATOPLASTY; PERFORATING KERATOPLASTY; SURGICAL TECHNIQUE; DEEP;
D O I
10.1111/j.1442-9071.2010.02368.x
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
P>Corneal clouding or opacification is a prominent feature of mucopolysaccharidosis (MPS), particularly in MPS I and VI. In patients with marked corneal clouding and visual impairment, penetrating keratoplasty may be considered to improve the patient's vision, functional capacity and quality of life. In MPS, glycosaminoglycans mainly accumulate in the corneal stroma and not in Descemet's membrane or the endothelium, therefore deep anterior lamellar keratoplasty (DALK) may be preferred in these patients over penetrating keratoplasty. Although there are only limited data on the use of DALK in MPS (I and VI) patients, the results are generally favourable. Nonetheless, when deciding on whether to perform keratoplasty in patients with MPS, the risk of general anaesthesia due to potential concomitant cardio-pulmonary problems and cervical spine instability, the potential presence of other ocular manifestations that also impair vision (e.g. glaucoma, retinal degeneration and optic atrophy) and/or complications such as allograft rejection and the risk of re-opacification of the graft, all need to be taken into consideration. Limbal stem cell transplantation, which can be combined with keratoplasty, also holds potential promise in the treatment of these complex cases. A review of the indications, local and systemic risks, techniques of lamellar and penetrating keratoplasty, and the potential of limbal stem cell transplantation is provided in the context of corneal opacity in MPS.
引用
收藏
页码:52 / 62
页数:11
相关论文
共 50 条
  • [41] Simultaneous penetrating keratoplasty and amniotic membrane transplantation in eyes with a history of limbal stem cell deficiency
    Borderie, V. M.
    Levy, O.
    Georgeon, C.
    Bouheraoua, N.
    JOURNAL FRANCAIS D OPHTALMOLOGIE, 2018, 41 (07): : 583 - 591
  • [42] Characterization of the corneal surface in limbal stem cell deficiency and after transplantation of cultured allogeneic limbal epithelial cells
    Chen, Peng
    Zhou, Qingjun
    Wang, Junyi
    Zhao, Xiaowen
    Duan, Haoyun
    Wang, Yao
    Liu, Ting
    Xie, Lixin
    GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2016, 254 (09) : 1765 - 1777
  • [43] Characterization of the corneal surface in limbal stem cell deficiency and after transplantation of cultured allogeneic limbal epithelial cells
    Peng Chen
    Qingjun Zhou
    Junyi Wang
    Xiaowen Zhao
    Haoyun Duan
    Yao Wang
    Ting Liu
    Lixin Xie
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2016, 254 : 1765 - 1777
  • [44] Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency
    Tseng, SCG
    Prabhasawat, P
    Barton, K
    Gray, T
    Meller, D
    ARCHIVES OF OPHTHALMOLOGY, 1998, 116 (04) : 431 - 441
  • [45] Limbal Stem Cell Deficiency and Corneal Neovascularization
    Lim, Pauline
    Fuchsluger, Thomas A.
    Jurkunas, Ula V.
    SEMINARS IN OPHTHALMOLOGY, 2009, 24 (03) : 139 - 148
  • [46] Diagnosis of corneal limbal stem cell deficiency
    Kim, Kyeong Hwan
    Mian, Shahzad I.
    CURRENT OPINION IN OPHTHALMOLOGY, 2017, 28 (04) : 355 - 362
  • [47] Posterior lamellar endothelial keratoplasty - Corneal transplantation and refractive surgery intersect
    Steinert, Roger F.
    ARCHIVES OF OPHTHALMOLOGY, 2008, 126 (02) : 263 - 264
  • [48] Limbal stem cell transplantation and keratoprosthesis
    Moussa, Sarah
    ACTA OPHTHALMOLOGICA, 2019, 97
  • [49] Transplantation of human corneal limbal epithelial cell sheet harvested on synthesized carboxymethyl cellulose and dopamine in a limbal stem cell deficiency
    Lee, Hun
    Lee, Jae Hyuck
    Hong, Soyoung
    Sunwoo, Jeong Hye
    Kim, Hyun Tae
    Kim, Eun-Soon
    Kim, Jae Yong
    Hwang, Changmo
    Tchah, Hungwon
    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2021, 15 (02) : 139 - 149
  • [50] Midterm outcomes of penetrating keratoplasty following allogeneic cultivated limbal epithelial transplantation in patients with bilateral limbal stem cell deficiency
    Jun-Fa Xue
    Dong-Fang Li
    Ya-Ni Wang
    Chen Chen
    Ru-Fei Yang
    Qing-Jun Zhou
    Ting Liu
    Li-Xin Xie
    Yan-Ling Dong
    International Journal of Ophthalmology, 2021, (11) : 1690 - 1699