Secretion of cytokines by uroepithelial cells stimulated by Escherichia coli and Citrobacter spp.

被引:33
|
作者
Fünfstück, R
Franke, S
Hellberg, M
Ott, U
Knöfel, B
Straube, E
Sommer, M
Hacker, J
机构
[1] Univ Jena, Klin Innere Med 4, D-07740 Jena, Germany
[2] Univ Jena, Inst Med Mikrobiol, D-07740 Jena, Germany
[3] Univ Wurzburg, Inst Mol Infekt Biol, D-97070 Wurzburg, Germany
关键词
urinary tract infection; Escherichia coli; Citrobacter; uroepithelial cells; cytokine activation;
D O I
10.1016/S0924-8579(01)00301-6
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Urinary tract epithelial cells (T 24/83) are able to express interleukin (IL)-61 IL-X, platelet-derived growth factor (PDGF) and tumour necrosis factor-sc, but not IL-1 beta. IL-2, IL-4 and IL-IO in response to an infection with uropathogenic bacteria. The process of cytokine secretion is time dependent. with a significant increase in the cytokine activity after 60 min. The expression of virulence factors of the bacteria does not seem to play a role. The interaction between bacterial products (e.g. lipopolysaccharide) and/or bacterial adhesion mediated by adhesins and specific receptor molecules of cell surfaces may be responsible for the activity of mediator protein expression in the epithelial cells. The release of PDGF acid IL-8 was found to be higher when due to Escherichia coli HE 101 trough form than that caused by other bacterial strains. Citrobactor CB 3009 provoked the highest level of IL-6. The PDGF level correlated significantly with IL-6 and IL-8 values (Pe 0.001). There was a significant correlation between the time-dependent release of IL-6 and IL-8 (P < 0.05). In epithelial cytokine response to bacterial infection. the reaction of the epithelial cells may modify themselves (e.g. internalization of bacteria) and the immune-regulatory processes that are caused by infection and responsible for parenchymal injury. <(c)> 2001 Published by Elsevier Science B.V and International Society of Chemotherapy. All rights reserved.
引用
收藏
页码:253 / 258
页数:6
相关论文
共 50 条
  • [31] Inhibition of Adhesion of Uropathogenic Escherichia coli Bacteria to Uroepithelial Cells by Extracts from Cranberry
    Ermel, Gwennola
    Georgeault, Sylvie
    Inisan, Claude
    Besnard, Matthieu
    JOURNAL OF MEDICINAL FOOD, 2012, 15 (02) : 126 - 134
  • [32] Concentrations of Campylobacter spp., Escherichia coli, Enterococci, and Yersinia spp. in the Feces of Farmed Red Deer in New Zealand
    Pattis, Isabelle
    Moriarty, Elaine
    Billington, Craig
    Gilpin, Brent
    Hodson, Roger
    Ward, Nick
    JOURNAL OF ENVIRONMENTAL QUALITY, 2017, 46 (04) : 819 - 827
  • [33] In Vitro Antimicrobial Effect of Phenolic Extracts and Resistant Starch on Escherichia coli, Streptococcus spp., Bifidobacterium and Lactobacillus spp.
    Karamati Jabehdar, Samira
    Mirzaei Aghjehgheshlagh, Farzad
    Navidshad, Bahman
    Mahdavi, Ali
    Staji, Hamid
    KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, 2019, 25 (02) : 137 - 146
  • [34] GLYCOLIPID RECEPTORS FOR UROPATHOGENIC ESCHERICHIA-COLI ON HUMAN-ERYTHROCYTES AND UROEPITHELIAL CELLS
    LEFFLER, H
    SVANBORGEDEN, C
    INFECTION AND IMMUNITY, 1981, 34 (03) : 920 - 929
  • [35] Resistance to antibiotics in strains of Staphylococcus spp., Enterococcus spp. and Escherichia coli isolated from rectal swabs of pigs
    Kolar, M.
    Bardon, J.
    Vagnerova, I.
    Sauer, P.
    Koukalova, D.
    Petrzelova, J.
    Cekanova, L.
    Pospisil, R.
    ACTA VETERINARIA BRNO, 2008, 77 (01) : 103 - 110
  • [36] Short communication: A comparison of the rate of polyethylene decomposition among Bacillus spp., Pseudomonas spp., and Escherichia coli bacteria
    Philander, Michael
    Ragobeeiv, Paulette
    Daniel, Ruth
    NUSANTARA BIOSCIENCE, 2019, 11 (01) : 97 - 100
  • [37] Occurrence of Vibrio spp., Aeromonas hydrophila, Escherichia coli and Campylobacter spp. in crayfish (Astacus leptodactylus) from Iran
    Raissy, M.
    Khamesipour, F.
    Rahimi, E.
    Khodadoostan, A.
    IRANIAN JOURNAL OF FISHERIES SCIENCES, 2014, 13 (04): : 944 - 954
  • [38] Prevalence of Salmonella spp. and Escherichia coli in dogs with diarrhoea in Western Taiwan
    Ting, Chiu-Huang
    Lin, Chia-Ying
    Chung, Chia-Wen
    Shen, Perng-Chih
    Chang, Ching-Dong
    Wu, Hung-Yi
    THAI JOURNAL OF VETERINARY MEDICINE, 2020, 50 (02): : 227 - 232
  • [39] The Temporal Dynamics of Slightly Deleterious Mutations in Escherichia coli and Shigella spp.
    Balbi, Kevin J.
    Rocha, Eduardo P. C.
    Feil, Edward J.
    MOLECULAR BIOLOGY AND EVOLUTION, 2009, 26 (02) : 345 - 355
  • [40] Relationship among Shigella spp. and enteroinvasive Escherichia coli (EIEC) and their differentiation
    Ud-Din, Abu
    Wahid, Syeda
    BRAZILIAN JOURNAL OF MICROBIOLOGY, 2014, 45 (04) : 1131 - 1138