Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation

被引：9
|
作者：
Bancos, Simona [1 ]
Phipps, Richard P. [1 ]
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY 14642 USA
来源：
CELLULAR IMMUNOLOGY | 2010年 / 266卷 / 01期
关键词：
Human B cells; Elderly; Cyclooxygenase-2; Antibody production; IL-6; IL-10; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANTIBODY-PRODUCTION; AGED MICE; IMMUNITY; LYMPHOCYTES; PREVENTION; LONGEVITY; RESPONSES;
D O I：
10.1016/j.cellimm.2010.09.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Worldwide the elderly population is increasing. The elderly show deficiencies in immune function. B lymphocytes are essential elements of the immune system responsible for antibody production. This laboratory previously showed that activated human B cells isolated from young adults express cyclooxygenase-2 (Cox-2) and that Cox-2 is essential for optimal antibody responses. Recent data suggests that Cox-2 expression decreases with age in mouse bone tissue. There is no information regarding Cox-2 expression in B cells from older human subjects. We investigated the expression and activity of Cox-2 in naive and memory B cells from older people. We show that B cells from older subjects show similar Cox-2 protein expression and activity, antibody production and proliferation compared to younger people. However, we found that activated memory B cells from older people produce higher levels of IL-6 and IL-10 compared to young adults. Therefore, the dysregulated cytokine production could contribute to immune senescence in the elderly. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：90 / 97
页数：8
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