Synthesis of N1-(3-chloro-4-flourophenyl)-N4-substituted semicarbazones as novel anticonvulsant agents

Several 3-chloro-4-flourophenyl substituted semicarbazones have been synthesized in three steps involving aryl urea and aryl semicarbazide Formation. The structures have been confirmed by spectral and elemental analyses. Some selected compounds have been evaluated or anticonvulsant activity by using maximal electroshock seizure. (MES) test. The compounds have also been screened for their neurotoxicity and CNS depressant activity. Compound 3i. N-1-(3-chloro-4-fluorophenyl)-N-1-(4-N,N-dimethylamino-benzaldehyde) semicarbazone is found most active of the series without neurotoxicity and less CNS depressant effect as compared to standard drug.