Enantioselective synthesis of hyperparathyroidism agent Cinacalcet hydrochloride

被引：0
|
作者：
Ganesh, N. S. [1 ]
Spandana, K. V. L. D. [1 ]
Narsaiah, A. Venkat [1 ]
机构：
[1] CSIR, Fluoro Agrochan Dept, Organ Synth Lab, Indian Inst Chem Technol, Hyderabad 500007, India
来源：
INDIAN JOURNAL OF CHEMISTRY | 2022年 / 61卷 / 05期
关键词：
Wittig reaction; CBS-reduction; oxidation; reductive amination; hyperparathyroidism; CALCIMIMETIC AGENT; ALDEHYDES; EFFICIENT; ALCOHOLS; ROUTE;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient route has been developed for enantioselective synthesis of hyperparathyroidism agent (R)-Cinacalcet. The synthesis started from commercially available triflouromethyl benzaldehyde and 1-(naphthalen-1-yl) ethanone and completed in 8 steps with an overall yield 18.5%. The key reactions involved are Corey-Bakshi-Shibata chiral reduction and reductive amination.
引用
收藏
页码：503 / 507
页数：5
相关论文
共 50 条
  • [41] Cinacalcet in the management of primary hyperparathyroidism
    Cetani, Filomena
    Marcocci, Claudio
    EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, 2012, 7 (01) : 45 - 53
  • [42] Lithium hypercalcemia, hyperparathyroidism, and cinacalcet
    Gregoor, P. Smak
    de Jong, G. M. T.
    KIDNEY INTERNATIONAL, 2007, 71 (05) : 470 - 470
  • [43] Enantioselective synthesis of (R)-phenylephrine hydrochloride
    Pandey, RK
    Upadhyay, PK
    Kumar, P
    TETRAHEDRON LETTERS, 2003, 44 (33) : 6245 - 6246
  • [44] Cinacalcet effect on severe hyperparathyroidism
    Al Saran, Khalid
    Sabry, Alaa
    Yehia, Ahmed
    Molhem, Azeb
    SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION, 2010, 21 (05) : 867 - 871
  • [45] Cinacalcet Treatment of Primary Hyperparathyroidism
    Rothe, H. M.
    Liangos, O.
    Biggar, P.
    Petermann, A.
    Ketteler, M.
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2011, 2011
  • [46] Enantioselective synthesis of (R)-salbutamol hydrochloride
    Cheng, Qing-Fang
    Wang, Qi-Fa
    Xu, Xing-You
    Ye, Yan-Bin
    Zhang, Hui
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2007, 27 (12) : 1558 - 1561
  • [47] Cinacalcet for Hyperparathyroidism in Pregnancy and Puerperium
    Horjus, Carmen
    Groot, Inge
    Telting, Darryl
    van Setten, Petra
    van Sorge, Adriaan
    Kovacs, Christopher S.
    Hermus, Ad
    de Boer, Hans
    JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2009, 22 (08): : 741 - 749
  • [48] Hypercalcemia due to resistant hyperparathyroidism in renal transplant patients treated with the calcimimetic agent cinacalcet
    Apostolou, T.
    Kollia, K.
    Damianou, L.
    Kaitsioti, H.
    Kotsiev, V.
    Dracopoulos, S.
    Vougas, V.
    Hadjiconstantinou, V.
    TRANSPLANTATION PROCEEDINGS, 2006, 38 (10) : 3514 - 3516
  • [49] Hypercalcemia due to resistant hyperparathyroidism in renal transplant patients treated with the calcimimetic agent cinacalcet
    Apostolou, Theofanis
    Kollia, Kyriaki
    Damianou, Loukas
    Kaitsioti, Helen
    Kotsiev, Vasa
    Drakopoulos, Spiros
    Vougas, Vassilios
    Hadjiconstantinou, Valsamakis
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 : 531 - 531
  • [50] Morphological changes of parathyroid hyperplasia in secondary hyperparathyroidism after calcium-mimetics (cinacalcet hydrochloride) administration
    Mitani, Kohji
    Hoshiyama, Ayako
    Matsunaga, Hajime
    Daikoku, Harumi
    Kitaoka, Masafumi
    ENDOCRINE JOURNAL, 2010, 57 : S490 - S490
12345