Serum paraoxonase 1 and butyrylcholinesterase in dogs with hyperadrenocorticism

被引：6

作者：

Tvarijonaviciute, Asta ^{[1
]}

Caldin, Marco ^{[2
]}

Martinez-Subiela, Silvia ^{[3
]}

Tecles, Fernando ^{[3
]}

Pastor, Josep ^{[1
]}

Ceron, Jose J. ^{[3
]}

机构：

[1] Univ Autonoma Barcelona, Dept Med & Cirugia Anim, E-08193 Barcelona, Spain

[2] San Marco Vet Hosp, Padua, Italy

[3] Univ Murcia, Fac Vet Med, Interlab UMU, E-30100 Murcia, Spain

来源：

VETERINARY JOURNAL | 2015年 / 203卷 / 02期

关键词：

Canine; Butyrylcholinesterase; Paraoxonase; 1; Hyperadrenocorticism; INFLAMMATION;

D O I：

10.1016/j.tvjl.2014.12.002

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The aim of this study was to evaluate serum activities of paraoxonase 1 (PON1) using three substrates; (1) 4-nitrophenylacetate (PON1n), (2) phenylacetate (PON1p), and (3) 5-thiobutyl butyrolactonase (PON1t), and butyrylcholinesterase (BChE) in dogs with hyperadrenocorticism (HAC). Serum activities of PON1 and BChE were higher in dogs with HAC than healthy dogs. There were strong positive correlations between PON1 activity measured with the three different substrates. This study demonstrated increased serum PON1 and BChE activities in dogs with HAC that could be attributed to the direct effect of glucocorticoids and lipid mobilisation. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：262 / 263

页数：2

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