Fluorescent metal-based complexes as cancer probes

被引：27
|
作者：
de Almeida, Andreia [1 ]
Bonsignore, Riccardo [2 ]
机构：
[1] Cardiff Univ, Sch Med, Div Canc & Genet, Tumour Microenvironm Grp, Tenovus Bldg, Cardiff CF14 4XN, Wales
[2] Cardiff Univ, Sch Chem, Pk Pl, Cardiff CF10 3AT, Wales
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2020年 / 30卷 / 13期
基金：
欧盟地平线“2020”; 英国惠康基金;
关键词：
Fluorescent probes; Metal complexes; Theranostics; Targeting; Metal-based probes; Anticancer probes; Fluorescence microscopy; RUTHENIUM(II) POLYPYRIDYL COMPLEXES; DNA-BINDING; PHOSPHORESCENT SENSOR; IRIDIUM(III) COMPLEX; ZINC(II) COMPLEXES; DUPLEX-DNA; ANTICANCER; NICKEL(II); COPPER(II); PHOTOSENSITIZERS;
D O I：
10.1016/j.bmcl.2020.127219
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The ability to track drugs inside of cells and tumours has been highly valuable in cancer research and diagnosis. Metal complexes add attractive features to fluorescent drugs, such as targeting and specificity, solubility and uptake or photophysical properties. This review focuses on the latest fluorescent metal-based complexes, their cellular targets, photophysical properties and possible anticancer effects.
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页数：12
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