Effects of Combined Treatment with Resveratrol and Indole-3-Carbinol

被引：6
|
作者：
Trusov, N. V. [1 ]
Guseva, G. V. [1 ]
Aksenov, I. V. [1 ]
Avren'eva, L. I. [1 ]
Kravchenko, L. V. [1 ]
Tutelyan, V. A. [1 ]
机构：
[1] Russian Acad Med Sci, Inst Nutr, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 149卷 / 02期
关键词：
resveratrol; indole-3-carbinol; xenobiotic metabolism enzymes; antioxidant state; NRF2; ANTIOXIDANT; ACTIVATION; EXPRESSION; TOXICITY; RECEPTOR; RNA;
D O I：
10.1007/s10517-010-0910-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Male Wistar rats received a semisynthetic diet with resveratrol (100 mg/kg), indole-3-carbinol (20 mg/kg), or a mixture of these compounds in the same doses for 1 week. Activities of ethoxyresorufin dealkylase (EROD), methoxyresorufin dealkylase (MROD), pentoxyresorufin dealkylase (PROD), and 6 beta-testosterone hydroxylase (6 beta-TH) and the content of mRNA for CYP1A1, CYP1A2, and CYP3A1 were elevated in the liver of rats receiving indole-3-carbinol. These changes were accompanied by an increase in activity of phase II xenobiotic metabolism enzymes (quinone reductase, hemoxygenase-1, glutathione transferase, and UDP glucuronosyl transferase). Resveratrol did not modify activity of these enzymes. After combined treatment with the test compounds, resveratrol suppressed the indole-3-carbinol-induced increase in activities of EROD, MROD, PROD, and 6 beta-TH, and expression of the corresponding genes. Combined treatment was characterized by potentiation of the antioxidant effects of these compounds.
引用
收藏
页码：213 / 218
页数：6
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