Positive effects of allosteric modulators on the binding properties and the function of muscarinic acetylcholine receptors

被引：10
|
作者：
Tucek, S
Jakubik, J
Dolezal, V
El-Fakahany, EE
机构：
[1] Inst Physiol AV CR, Prague 14220, Czech Republic
[2] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA
来源：
JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 3-4期
关键词：
muscarinic receptors; presynaptic receptors; allosteric regulation; alcuronium; acetylcholine;
D O I：
10.1016/S0928-4257(98)80026-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Data are reviewed indicating that allosteric modulators can enhance the affinities of muscarinic receptors for their antagonists and agonists, that the enhancement of the affinity for agonists is relevant functionally, and that the allosterically induced conformational change also affects the interaction between the receptors and the G proteins. ((C)Elsevier, Paris).
引用
收藏
页码：241 / 243
页数：3
相关论文
共 50 条
  • [41] The affinity of muscarinic receptors for their agonists can be increased by allosteric modulators
    Jakubik, J
    Bacakova, L
    ElFakahany, EE
    Tucek, S
    JOURNAL OF NEUROCHEMISTRY, 1997, 69 : S240 - S240
  • [42] Interaction of cationic allosteric modulators of muscarinic receptors with an anionic interphase
    Mieskes, A
    Tränkle, C
    Mohr, K
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 357 (04) : R23 - R23
  • [43] Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: A new target for a privileged structure
    Balsera, Beatriz
    Mulet, Jose
    Fernandez-Carvajal, Asia
    de la Torre-Martinez, Roberto
    Ferrer-Montiel, Antonio
    Hernandez-Jimenez, Jose G.
    Estevez-Herrera, Judith
    Borges, Ricardo
    Freitas, Andiara E.
    Lopez, Manuela G.
    Teresa Garcia-Lopez, M.
    Gonzalez-Muniz, Rosario
    Perez de Vega, Maria Jesus
    Valor, Luis M.
    Svobodova, Lucie
    Sala, Salvador
    Sala, Francisco
    Criado, Manuel
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 86 : 724 - 739
  • [44] Characterization of type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors
    Young, Gareth T.
    Millar, Neil S.
    BIOCHEMICAL PHARMACOLOGY, 2009, 78 (07) : 914 - 914
  • [45] Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors
    Disingrini, T
    Muth, M
    Dallanoce, C
    Barocelli, E
    Bertoni, S
    Kellershohn, K
    Mohr, K
    De Amici, M
    Holzgrabe, U
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (01) : 366 - 372
  • [46] FUNCTION OF MUSCARINIC AND NICOTINIC ACETYLCHOLINE RECEPTORS
    PURVES, RD
    NATURE, 1976, 261 (5556) : 149 - 151
  • [47] Allosteric regulation of the binding of [H-3]acetylcholine to m2 muscarinic receptors
    Gnagey, A
    Ellis, J
    BIOCHEMICAL PHARMACOLOGY, 1996, 52 (11) : 1767 - 1775
  • [48] Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors
    Larsen, Anja Probst
    Fievre, Sabine
    Frydenvang, Karla
    Francotte, Pierre
    Pirotte, Bernard
    Kastrup, Jette Sandholm
    Mulle, Christophe
    MOLECULAR PHARMACOLOGY, 2017, 91 (06) : 576 - 585
  • [49] Characterization of novel selective positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR)
    Brady, Ashley Elizabeth
    Bridges, Tom M.
    Jones, Carrie K.
    Shirey, Jana K.
    Lindsley, Craig W.
    Conn, P. Jeffrey
    FASEB JOURNAL, 2008, 22
  • [50] THE USE OF COGNITIVE AND ERP BIOMARKERS OF CHOLINERGIC FUNCTION IN NOVEL TESTS OF MUSCARINIC POSITIVE ALLOSTERIC MODULATORS
    Conley, Alexander
    Key, Alexandra
    Conn, P. Jeffrey
    Lindsley, Craig
    Jones, Carrie
    Newhouse, Paul
    AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2019, 27 (03): : S91 - S91
12345