Antibody-mediated rejection of the cardiac allograft: where do we stand in 2012?

被引：7

作者：

Berry, Gerald J. ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Stanford, CA 94306 USA

来源：

CURRENT OPINION IN ORGAN TRANSPLANTATION | 2012年 / 17卷 / 03期

关键词：

antibody-mediated rejection; complement deposition; grading scheme; heart transplantation and allograft; immunofluorescence; immunohistochemistry; HUMORAL REJECTION; HEART-TRANSPLANTATION; WORKING FORMULATION; DIAGNOSIS; BIOPSY; PARAMETERS; COMPLEMENT;

D O I：

10.1097/MOT.0b013e328353660f

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Purpose of review The review will discuss the current pathological criteria for the diagnosis and classification of antibody-mediated rejection (AMR) in the cardiac allograft. Recent findings Until recently, the diagnosis of AMR required clinical dysfunction, presence of donor specific antibodies and pathological alterations. The concept of asymptomatic AMR and its adverse long-term outcomes created, in part the need to reevaluate diagnostic criteria. The results of a recent consensus meeting sponsored by International Society For Heart And Lung Transplantation are discussed. Summary The diagnosis of AMR rests on histopathological and immunophenotypic findings. These provide the basis for a new grading scheme.

引用

页码：303 / 308

页数：6

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