Acne vulgaris is one of the most common skin disorders. Prevalence is reported at between 35% and 90% in adolescents. The pathogenesis of acne is complex, multifactorial and still unclear. The genetic influence on pathogenesis of acne is well documented in the case of twins and in genealogic studies. There are only a few reports concentrating on the association between acne and genes. The relationship of acne and HLA, CYP1A1, CYP17, CYP21, MUC1, AR and MC5-R genes was investigated. We present a review of the role of genetic factors in the aetiopathogenesis of acne.
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Nottingham Univ Hosp NHS Trust, Ctr Evidence Based Dermatol, Nottingham NG7 2UH, EnglandNottingham Univ Hosp NHS Trust, Ctr Evidence Based Dermatol, Nottingham NG7 2UH, England
Williams, Hywel C.
Dellavalle, Robert P.
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Univ Colorado Denver, Sch Med, Aurora & VA Eastern Colorado Hlth Care Syst, Dept Dermatol, Denver, CO USANottingham Univ Hosp NHS Trust, Ctr Evidence Based Dermatol, Nottingham NG7 2UH, England
Dellavalle, Robert P.
Garner, Sarah
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Tufts Med Ctr, Ctr Evaluat Value & Risk Hlth, Boston, MA USA
Commonwealth Fund, New York, NY USANottingham Univ Hosp NHS Trust, Ctr Evidence Based Dermatol, Nottingham NG7 2UH, England