Nanofluidic biosensing for β-amyloid detection using surface enhanced Raman spectroscopy

被引：179
|
作者：
Chou, I-Hsien [1 ]
Benford, Melodie [1 ]
Beier, Hope T. [1 ]
Cote, Gerard L. [1 ]
Wang, Miao [2 ]
Jing, Nan [2 ]
Kameoka, Jun [2 ]
Good, Theresa A. [3 ]
机构：
[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA
[2] Texas A&M Univ, Dept Elect Engn, College Stn, TX 77843 USA
[3] Univ Maryland Baltimore Cty, Dept Chem & Biochem Engn, Baltimore, MD 21250 USA
来源：
NANO LETTERS | 2008年 / 8卷 / 06期
关键词：
D O I：
10.1021/nl0808132
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Trace detection of the conformational transition of beta-amyloid peptide (A beta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe A beta in different conformational states during the A beta self-assembly process as well as to distinguish A beta from confounder proteins commonly found in cerebral spinal fluid.
引用
收藏
页码：1729 / 1735
页数：7
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