Precise Functionalization of Remote C-H Bonds

被引：1
|
作者：
Liu, Zeshui [1 ]
Cheng, Honggang [1 ]
Zhou, Qianghui [1 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2020年 / 36卷 / 04期
关键词：
ACTIVATION;
D O I：
10.1007/s40242-020-0158-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Remote C-H bond functionalization of arenes with precise control is a recognized extraordinary challenge in organic synthesis. Recently, Yu and Houk et al. developed an elegant strategy to distinguish and functionalize remote C-sp(2)-H bonds of (hetero)arenes within one-bond distance by the interplay of a remote directing template and a transient norbornene-type mediator. A wide range of medicinally important benzoazines are well compatible with this method. The chemistry significantly expands the toolbox for site-selective functionalization of remote C-sp(2)-H bond of (hetero)arenes. This work has been published in Nature Chemistry in March, 2020.
引用
收藏
页码：727 / 728
页数：2
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