Assessment of control strategies against Clonorchis sinensis infection based on a multi-group dynamic transmission model

Clonorchiasis is one of the most important food-borne trematodiases affecting millions of people. Strategies were recommended by different organizations and control programmes were implemented but mostly in short-time periods. It's important to assess the long-term benefits and sustainability of possible control strategies on morbidity control of the disease. We developed a multi-group transmission model to describe the dynamics of C. sinensis transmission among different groups of people with different raw-fish-consumption behaviors, based on which, a full model with interventions was proposed and three common control measures (i.e., preventive chemotherapy, information, education, and communication (IEC) and environmental modification) and their possible combinations were considered. Under a typical setting of C. sinensis transmission, we simulated interventions according to different strategies and with a series of values of intervention parameters. We found that combinations of measures were much beneficial than those singly applied; higher coverages of measures had better effects; and strategies targeted on whole population performed better than that on at-risk population with raw-fish-consumption behaviors. The strategy recommended by the government of Guangdong Province, China shows good and sustainable effects, under which, the infection control (with human prevalence <5%) could be achieved within 7.84 years (95% CI: 5.78-12.16 years) in our study setting (with original observed prevalence 33.67%). Several sustainable strategies were provided, which could lead to infection control within 10 years. This study makes the effort to quantitatively assess the long-term effects of possible control strategies against C. sinensis infection under a typical transmission setting, with application of a multi-group dynamic transmission model. The proposed model is easily facilitated with other transmission settings and the simulation outputs provide useful information to support the decision-making of control strategies on clonorchiasis. Author summary Clonorchiasis is an important food-borne parasitic disease. People get infected mainly through eating raw and infected fish, thus different behaviors of raw-fish-consumption play an important role on transmission. It's critical to find effective and sustainable control strategies for morbidity control of the disease. Control programmes have been implemented in endemic areas mostly in short periods, which is difficult to assess their long-term benefits and sustainability. We developed a multi-group model depicting transmission dynamics of the disease among different groups of people with different raw-fish-consumption behaviors, based on which, long-term effects of possible control strategies were simulated and assessed. Under a typical transmission setting, we found that combinations of control measures were much beneficial than those singly applied; higher coverages of measures had better effects; and strategies targeted on whole population performed better than that on at-risk population with raw-fish-consumption behaviors. The strategy recommended by the government of Guangdong Province, China shows good and sustainable effects. Besides, several sustainable strategies are provided under the study setting. The proposed transmission model is easily facilitated with other transmission settings. The simulation outputs can be considered together with actual practical situations to support decision making on selection of effective control strategies on clonorchiasis.