Cu(OTf)2-catalyzed arylmethylation of terminal alkynes with benzylic alcohols under ligand-, base-, and additive-free reaction conditions

被引：32
|
作者：
Ren, Kai [1 ]
Li, Pinhua [1 ]
Wang, Lei [1 ,3 ]
Zhang, Xiuli [2 ]
机构：
[1] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China
[2] Anhui Agr Univ, Coll Sci, Hefei 230036, Anhui, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
TETRAHEDRON | 2011年 / 67卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Arylmethylation; Benzylic alcohols; C-C bond formation; Cu(OTf)(2); Terminal alkynes; CROSS-COUPLING REACTION; SELECTIVE METHOD; BOND FORMATION; IN-SITU; HALIDES; EFFICIENT; ELECTROPHILES; DERIVATIVES; IODIDES; ORGANOMETALLICS;
D O I：
10.1016/j.tet.2011.02.050
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An effective, convenient, and mild coupling reaction of benzylic alcohols with terminal alkynes has been developed. As an effective Lewis acid, Cu(OTF)(2)-catalyzed arylmethylation of terminal alkynes with benzylic alcohols generated the corresponding products in BrCH2CH2Br with good yields in the absence of ligand, base, and additive. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2753 / 2759
页数：7
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