Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages

被引:4
|
作者
Shu, Yuxin [1 ,2 ,3 ]
Yang, Nanfei [1 ,2 ]
Cheng, Nan [1 ,2 ]
Zou, Zhengyun [1 ,2 ]
Zhang, Wenlong [1 ,2 ]
Bei, Yuncheng [1 ,2 ]
Shi, Qian [4 ]
Qin, Menghao [1 ,2 ]
Zhu, Wei-Guo [3 ]
Shen, Pingping [1 ,2 ]
机构
[1] Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Med Sch,Sch Life Sci,State Key Lab Pharmaceut Bio, Nanjing 210023, Peoples R China
[2] Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Med Sch,Sch Life Sci,Comprehens Canc Ctr, Nanjing 210023, Peoples R China
[3] Shenzhen Univ, Guangdong Key Lab Genome Instabil & Human Dis, Int Canc Ctr, Dept Biochem & Mol Biol, Shenzhen 518060, Peoples R China
[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Integrat Physiol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA
关键词
D O I
10.1038/s41392-021-00807-w
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [31] Targeting tumor-associated macrophages in the tumor microenvironment
    Zhou, Kaiwen
    Cheng, Tan
    Zhan, Jinyue
    Peng, Xuan
    Zhang, Yue
    Wen, Jianpei
    Chen, Xiaoman
    Ying, Muying
    [J]. ONCOLOGY LETTERS, 2020, 20 (05)
  • [32] Tumor promoting role of anti-tumor macrophages in tumor microenvironment
    Goswami, Kuntal Kanti
    Ghosh, Tithi
    Ghosh, Sarbari
    Sarkar, Madhurima
    Bose, Anamika
    Baral, Rathindranath
    [J]. CELLULAR IMMUNOLOGY, 2017, 316 : 1 - 10
  • [33] FoxO1 is a regulator of MHC-II expression and anti-tumor effect of tumor-associated macrophages
    Yang, Jing-Bo
    Zhao, Zhi-Bin
    Liu, Qing-Zhi
    Hu, Tai-Dou
    Long, Jie
    Yan, Kai
    Lian, Zhe-Xiong
    [J]. ONCOGENE, 2018, 37 (09) : 1192 - 1204
  • [34] TARGETING THE EXTRACELLULAR MATRIX OF GLIOBLASTOMAS CHANGES THE POLARIZATION OF TUMOR-ASSOCIATED MACROPHAGES AND INCREASES ANTI-TUMOR INFLAMMATORY RESPONSES
    Arivazhagan, Roshini
    Nandhu, Mohan
    Longo, Sharon
    Chin, Lawrence
    Viapiano, Mariano
    [J]. NEURO-ONCOLOGY, 2018, 20 : 264 - 264
  • [35] Phosphatidylserine and/or Sialic Acid Modified Liposomes Increase Uptake by Tumor-associated Macrophages and Enhance the Anti-tumor Effect
    Xu, Zihan
    Li, Jie
    Yan, Na
    Liu, Xinrong
    Deng, Yihui
    Song, Yanzhi
    [J]. AAPS PHARMSCITECH, 2024, 25 (05):
  • [36] Exosome-Mediated Delivery of Antisense Oligonucleotides Reprograms Tumor-Associated Macrophages and Induces Anti-Tumor Responses
    Kamerkar, Sushrut
    Burzyn, Dalia
    Leng, Charan
    Burenkova, Olga
    Jang, Su Chul
    Yang, Raymond
    Kirwin, Katherine
    Zi, Tong
    Dahlberg, William
    Zhang, Eric
    Estes, Scott
    Economides, Kyriakos
    Soos, Timothy
    Sathyanarayanan, Sriram
    [J]. MOLECULAR THERAPY, 2020, 28 (04) : 467 - 468
  • [37] Natural Killer T (NKT) cells mediate anti-tumor activity via killing of tumor-associated macrophages
    Metelitsa, Leonid S.
    Song, Liping
    Salo, Jill
    Engell, Kelly
    Wu, Hong-wei
    Sposto, Richard
    Seeger, Robert C.
    Asgharzadeh, Shahab
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 182
  • [38] FoxO1 is a regulator of MHC-II expression and anti-tumor effect of tumor-associated macrophages
    Jing-Bo Yang
    Zhi-Bin Zhao
    Qing-Zhi Liu
    Tai-Dou Hu
    Jie Long
    Kai Yan
    Zhe-Xiong Lian
    [J]. Oncogene, 2018, 37 : 1192 - 1204
  • [39] Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
    Zhong, Wenqun
    Lu, Youtao
    Han, Xuexiang
    Yang, Jingbo
    Qin, Zhiyuan
    Zhang, Wei
    Yu, Ziyan
    Wu, Bin
    Liu, Shujing
    Xu, Wei
    Zheng, Cathy
    Schuchter, Lynn M.
    Karakousis, Giorgos C.
    Mitchell, Tara C.
    Amaravadi, Ravi
    Flowers, Ahron J.
    Gimotty, Phyllis A.
    Xiao, Min
    Mills, Gordon
    Herlyn, Meenhard
    Dong, Haidong
    Mitchell, Michael J.
    Kim, Junhyong
    Xu, Xiaowei
    Guo, Wei
    [J]. CELL REPORTS, 2023, 42 (10):
  • [40] IL-28B reprograms tumor-associated macrophages to promote anti-tumor effects in colon cancer
    Cheng, Dalei
    Wang, Haiyan
    Cheng, Hongyan
    Zhang, Hui
    Dong, Guanjun
    Yan, Fenglian
    Ning, Zhaochen
    Wang, Changying
    Wei, Li
    Zhang, Xin
    Zhang, Junfeng
    Xiong, Huabao
    [J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 109