Preliminary results of a phase II clinical trial of Genz-112638 in patients with type I Gaucher disease

被引：1
|
作者：
Peterschmitt, Judith [1 ,8 ]
Lukina, Elena [2 ,8 ]
Watman, Nora [3 ,8 ]
Banikazemi, Maryam [4 ,8 ]
Iastrebner, Marcelo [5 ,8 ]
Rosenbaum, Hanna [6 ,8 ]
Zimran, Ari [7 ,8 ]
Arreguin, Elsa Avila [7 ,8 ]
O'Brien, Fanny [1 ,8 ]
Smith, Sharon [1 ,8 ]
Puga, Ana Cristina [1 ,8 ]
机构：
[1] Genzyme Corp, Cambridge, MA USA
[2] Russian Acad Med Sci, Hematol Res Ctr, Moscow, Russia
[3] Hosp Ramos Mejia, Buenos Aires, DF, Argentina
[4] NYU, New York, NY USA
[5] Inst Argentino Diagnost & Tratamiento, Buenos Aires, DF, Argentina
[6] Rambam Med Ctr, Haifa, Israel
[7] Shaare Zedek Med Ctr, Jerusalem, Israel
[8] Seguro Social Hosp Especialidades, Inst Mexicano, Col La Raza, Mexico
来源：
MOLECULAR GENETICS AND METABOLISM | 2008年 / 93卷 / 02期
关键词：
D O I：
10.1016/j.ymgme.2007.10.085
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
73
引用
收藏
页码：S32 / S33
页数：2
相关论文
共 50 条
  • [1] PRELIMINARY RESULTS OF A PHASE II CLINICAL TRIAL OF GENZ-112638 IN PATIENTS WITH TYPE 1 GAUCHER DISEASE
    Puga, A. Cristina
    Lukina, E.
    Watman, N.
    Banikazemi, M.
    Iastrebner, M.
    Rosenbaum, H.
    Zimran, A.
    Arreguin, E. Avila
    O'Brien, F.
    Smith, S. E.
    Peterschmitt, J.
    CLINICAL THERAPEUTICS, 2008, 30 : S103 - S104
  • [2] Preliminary results of a phase 2 clinical trial of Genz-112638 in patients with type I Gaucher disease
    Lukina, E.
    Watman, N.
    Arreguin, E. A.
    Banikazemi, M.
    Iastrebner, M.
    Rosenbaum, H.
    Zimran, A.
    O'Brien, F.
    Smith, S. E.
    Puga, A. C.
    Peterschmitt, J.
    JOURNAL OF INHERITED METABOLIC DISEASE, 2008, 31 : 114 - 114
  • [3] Genz-112638, an investigational oral treatment for Gaucher disease type 1: Preliminary Phase 2 clinical trial results
    Peterschmitt, Judith
    Lukina, Elena
    Watman, Nora
    Arreguin, Elsa
    Banikazemi, Maryam
    Pastores, Gregory
    Lastrebner, Marcelo
    Dragosky, Marta
    Rosenbaum, Hanna
    Zimran, Ari
    O'Brien, Fanny
    Smith, Sharon
    Puga, Ana Cristina
    MOLECULAR GENETICS AND METABOLISM, 2009, 96 (02) : S34 - S34
  • [4] Preliminary results of a phase 2 clinical trial of Genz-112638 in patients 2 with Type I vGaucher disease.
    Banikazemi, Maryam
    Lukina, Elena
    Watman, Nora
    Lastrebrier, Marcelo
    Rosenbamn, Hanna
    Zimran, Ari
    Arreguin, Elsa Avila
    O'Brien, Fanny
    Smith, Sharon E.
    Pugas, Ana Cristina
    Petersclimitt, Judith
    MOLECULAR GENETICS AND METABOLISM, 2008, 93 (03) : 240 - 241
  • [5] IMPROVEMENT OF BONE MANIFESTATIONS OF GAUCHER DISEASE TYPE I WITH GENZ-112638: PHASE 2 TRIAL RESULTS AT 1 YEAR
    Peterschmitt, J.
    Lukina, E.
    Watman, N.
    Arreguin, E. Avila
    Banikazemi, M.
    Pastores, G.
    Iasterbner, M.
    Rosenbaum, H.
    Phillips, M.
    Kaper, M.
    Smith, S. E.
    Puga, A. C.
    MOLECULAR GENETICS AND METABOLISM, 2009, 98 (1-2) : 80 - 80
  • [6] Genz-112638 for Gaucher Disease Type 1: Phase 2 Clinical Trial Results After 18 Months of Treatment.
    Peterschmitt, Judith
    Lukina, Elena
    Watman, Nora Patricia
    Arreguin, Elsa Avila
    Banikazemi, Maryam
    Pastores, Gregory
    Iastrebner, Marcelo
    Dragosky, Marta
    Rosenbaum, Hanna
    Phillips, Mici
    Kaper, Mathilde
    Singh, Tejdip
    Puga, Ana Cristina
    BLOOD, 2009, 114 (22) : 550 - 550
  • [7] Bone response to Genz-112638 in a Phase 2 study in Gaucher disease type 1
    Peterschmitt, M.
    Lukina, Elena
    Watman, Nora
    Avila Arreguin, Elsa
    Pastores, Gregory
    Iastrebner, Marcelo
    Dragosky, Marta
    Rosenbaum, Hanna
    Phillips, Mici
    Kaper, Mathilde
    Singh, Tejdip
    Puga, Ana Cristina
    MOLECULAR GENETICS AND METABOLISM, 2010, 99 (02) : S30 - S30
  • [8] GENZ-112638, AN INVESTIGATIONAL ORAL THERAPY FOR GAUCHER DISEASE TYPE 1: PHASE 2 CLINICAL TRIAL RESULTS AFTER ONE YEAR OF TREATMENT
    Lukina, E.
    Watman, N.
    Arreguin, E.
    Banikazemi, M.
    Pastores, G.
    Iastrebner, M.
    Dragosky, M.
    Rosenbaum, H.
    Zimran, A.
    Kaper, M.
    Smith, S. E.
    Puga, A. C.
    Peterschmitt, J.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 : 41 - 41
  • [9] Latest Data on Genz-112638, an Investigational Oral Therapy for Type 1 Gaucher Disease: Phase II Clinical Trial Results After 1 Year of Treatment
    Lukina, Elena
    CLINICAL THERAPEUTICS, 2009, 31 : S194 - S195
  • [10] GENZ-112638, an oral ceramide analog for substrate inhibition therapy of Gaucher disease
    Cheng, S. H.
    McEachern, K. M.
    Siegel, C.
    Fung, J.
    Komarnitsky, S.
    Chuang, W-L
    Johnson, J.
    Hutto, E.
    Grabowski, G. A.
    Zhang, K.
    Marshall, J.
    Sung, C.
    Peterschmitt, M. J.
    Copeland, D. P.
    JOURNAL OF INHERITED METABOLIC DISEASE, 2006, 29 : 20 - 20
12345