Poorly water-soluble drugs for oral delivery -: A challenge for pharmaceutical development

被引：0

作者：

Rasenack, N

Müller, BW

机构：

[1] Pharmatech GmbH, D-24220 Flintbek, Germany

[2] Univ Kiel, Dept Pharmaceut & Biopharmaceut, Kiel, Germany

来源：

PHARMAZEUTISCHE INDUSTRIE | 2005年 / 67卷 / 03期

关键词：

bioavailability; dissolution rate; oral drug delivery systems; in vitro and in vivo; characterization; poorly water-soluble drugs; solubility;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several New Chemical Entities (NCEs) in pharmaceutical research are poorly water-soluble which often results in an insufficient bioavailability from common oral dosage forms. This presents a challenge to develop suitable drug delivery systems for oral use which ensure that the drug has sufficient bioavailability. Several technologies exist for increasing the dissolution rate and/or the solubility. This review series in three parts presents pharmaceutical technologies and points out advantages and disadvantages.

引用

页码：323 / 326

页数：4

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