Poorly water-soluble drugs for oral delivery -: A challenge for pharmaceutical development

被引：0
|
作者：
Rasenack, N
Müller, BW
机构：
[1] Pharmatech GmbH, D-24220 Flintbek, Germany
[2] Univ Kiel, Dept Pharmaceut & Biopharmaceut, Kiel, Germany
来源：
PHARMAZEUTISCHE INDUSTRIE | 2005年 / 67卷 / 03期
关键词：
bioavailability; dissolution rate; oral drug delivery systems; in vitro and in vivo; characterization; poorly water-soluble drugs; solubility;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several New Chemical Entities (NCEs) in pharmaceutical research are poorly water-soluble which often results in an insufficient bioavailability from common oral dosage forms. This presents a challenge to develop suitable drug delivery systems for oral use which ensure that the drug has sufficient bioavailability. Several technologies exist for increasing the dissolution rate and/or the solubility. This review series in three parts presents pharmaceutical technologies and points out advantages and disadvantages.
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收藏
页码：323 / 326
页数：4
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