Citrinovirin with a new norditerpene skeleton from the marine algicolous fungus Trichoderma citrinoviride

被引：40
|
作者：
Liang, Xiao-Rui [1 ,2 ,3 ]
Miao, Feng-Ping [1 ]
Song, Yin-Ping [1 ,3 ]
Liu, Xiang-Hong [1 ]
Ji, Nai-Yun [1 ]
机构：
[1] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
[2] Naval Aeronaut & Astronaut Univ, Yantai 264001, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 20期
基金：
中国国家自然科学基金;
关键词：
Marine algicolous fungi; Trichoderma citrinoviride; Norditerpene; Citrinovirin; PAECILOMYCES-VARIOTII; NATURAL-PRODUCTS; DITERPENES; STRAIN;
D O I：
10.1016/j.bmcl.2016.08.093
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Citrinovirin (1), a novel norditerpene with an unprecedented carbon skeleton along with three known compounds, cyclonerodiol (2), 3-(2-hydroxypropyl)-4-(hexa-2E, 4E-dien-6-yl)furan-2(5H)-one (3), and 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (4), was isolated from the culture of a marine brown alga-endophytic strain (cf-27) of Trichoderma citrinoviride. The structure and relative configuration of 1 were identified by spectroscopic methods, including 1D/2D NMR and MS. Its absolute configuration was established by analysis of ECD spectrum, aided by quantum chemical calculations. A plausible biogenetic pathway is proposed for 1, and it was evaluated to be active against Staphylococcus aureus. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5029 / 5031
页数：3
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