Splicing it up: A variant of the N-type calcium channel specific for pain

被引：9

作者：

Zamponi, GW ^{[1
]}

McCleskey, EW

机构：

[1] Univ Calgary, Dept Physiol & Biophys Cellular, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Mol Neurobiol Res Grp, Calgary, AB T2N 4N1, Canada

[3] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97239 USA

来源：

NEURON | 2004年 / 41卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(03)00846-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

How would you make a drug that inhibits pain without side effects? The most obvious strategy for analgesia targets molecules that are expressed only on neurons used for pain. In this issue of Neuron, Bell et al. report a new splice variant of a calcium channel that controls neurotransmitter release and show that it is expressed primarily on nociceptors, the sensory neurons that trigger pain.

引用

页码：3 / 4

页数：2

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