First Example of Copper(I) Catalyzed Decarboalkoxymethylation of Alkyl 2-[1-(Pyridin-2-yl)-1H-pyrrol-2-yl]acetates

被引：3

作者：

Ali, Sk Asraf ^{[1
,2
]}

Bera, Anirban ^{[1
]}

Manna, Susanta Kumar ^{[1
]}

Santra, Subrata ^{[2
]}

Molla, Mijanur Rahaman ^{[2
]}

Samanta, Shubhankar ^{[1
]}

机构：

[1] Bidhannagar Coll, Dept Chem, Kolkata 700064, India

[2] Univ Calcutta, Dept Chem, Acharya Prafulla Chandra Rd, Kolkata 700009, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 18期

关键词：

Pyrrole; Decarboalkoxymethylation; Copper(I); Isolated intermediate; Open flask; CROSS-COUPLING REACTION; ARYL ESTERS; ACIDS; NICKEL; DECARBOXYLATION; PROTODECARBOXYLATION; TRANSFORMATIONS; CYCLIZATION; SILYLATION; CLEAVAGE;

D O I：

10.1002/ejoc.202000331

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we report an unprecedented functional group assisted decarboalkoxymethylation (-CH2CO2R) of N-pyridinyl pyrrolo esters by using air stable and cheap copper(I) catalyst. 2-formyl substituent of pyrrole unit is the key isolated intermediate for this novel transformation. This methodology is quick and tolerates a wide range of functional groups in open flask conditions. This protocol provides a large array of tricyclic N-pyridinyl 2, 5 unsubstituted fused pyrrole derivatives with high yield (up to 92 %).

引用

页码：2754 / 2760

页数：7

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