First Example of Copper(I) Catalyzed Decarboalkoxymethylation of Alkyl 2-[1-(Pyridin-2-yl)-1H-pyrrol-2-yl]acetates

被引：3
|
作者：
Ali, Sk Asraf [1 ,2 ]
Bera, Anirban [1 ]
Manna, Susanta Kumar [1 ]
Santra, Subrata [2 ]
Molla, Mijanur Rahaman [2 ]
Samanta, Shubhankar [1 ]
机构：
[1] Bidhannagar Coll, Dept Chem, Kolkata 700064, India
[2] Univ Calcutta, Dept Chem, Acharya Prafulla Chandra Rd, Kolkata 700009, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 18期
关键词：
Pyrrole; Decarboalkoxymethylation; Copper(I); Isolated intermediate; Open flask; CROSS-COUPLING REACTION; ARYL ESTERS; ACIDS; NICKEL; DECARBOXYLATION; PROTODECARBOXYLATION; TRANSFORMATIONS; CYCLIZATION; SILYLATION; CLEAVAGE;
D O I：
10.1002/ejoc.202000331
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report an unprecedented functional group assisted decarboalkoxymethylation (-CH2CO2R) of N-pyridinyl pyrrolo esters by using air stable and cheap copper(I) catalyst. 2-formyl substituent of pyrrole unit is the key isolated intermediate for this novel transformation. This methodology is quick and tolerates a wide range of functional groups in open flask conditions. This protocol provides a large array of tricyclic N-pyridinyl 2, 5 unsubstituted fused pyrrole derivatives with high yield (up to 92 %).
引用
收藏
页码：2754 / 2760
页数：7
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