Supratherapeutic Tacrolimus Concentrations With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients Requiring Hospitalization: A Case Series Using Rifampin for Reversal

被引：22

作者：

Rose, Dusten T. ^{[1
,2
]}

Gandhi, Saurin M. ^{[3
]}

Bedard, Rachael A. ^{[1
,4
]}

Mondy, Kristin E. ^{[5
]}

Chu, Alexander L. ^{[6
]}

Gamble, Kelly C. ^{[1
]}

Gee, Amanda T. ^{[1
]}

Kundra, Monica A. ^{[3
]}

Williams, Amber L. ^{[1
]}

Lee, Brian K. ^{[4
,7
]}

机构：

[1] Univ Texas Austin, Dept Pharm, Dell Seton Med, Ascension Seton, Austin, TX 78701 USA

[2] Univ Texas Austin, Coll Pharm, Austin, TX 78701 USA

[3] Univ Texas Austin, Dell Med Sch, Dept Internal Med, Austin, TX 78701 USA

[4] Univ Texas Austin, Dell Med Sch, Kidney & Pancreas Transplant Program, Austin, TX 78701 USA

[5] Univ Texas Austin, Dell Med Sch, Dept Internal Med, Div Infect Dis, Austin, TX 78701 USA

[6] Univ Texas Austin, Dell Med Sch, Dept Med Educ, Austin, TX 78701 USA

[7] Univ Texas Austin, Dell Seton Med Ctr, Dept Internal Med, Div Nephrol, Austin, TX 78701 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2022年 / 9卷 / 07期

关键词：

COVID-19; drug interactions; nirmatrelvir; ritonavir; tacrolimus; DRUG-INTERACTIONS; PHARMACOKINETICS;

D O I：

10.1093/ofid/ofac238

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nirmatrelvir/ritonavir was recently granted emergency use authorization for mild to moderate coronavirus disease 2019. Drug-drug interactions between ritonavir and tacrolimus are underappreciated by nontransplant providers. We describe 2 solid organ transplant recipients prescribed nirmatrelvir/ritonavir for outpatient use who developed tacrolimus toxicity requiring hospitalization and were managed with rifampin for toxicity reversal.

引用

页数：5

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