The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation

被引:9
|
作者
Podyma, Brandon [1 ]
Johnson, Dove-Anna [1 ]
Sipe, Laura [1 ,3 ]
Remcho, Thomas Parks [1 ,4 ]
Battin, Katherine [1 ]
Liu, Yuxi [2 ]
Yoon, Sung Ok [2 ]
Deppmann, Christopher D. [1 ]
Guler, Ali Deniz [1 ]
机构
[1] Univ Virginia, Dept Biol, Charlottesville, VA 22904 USA
[2] Ohio State Univ, Coll Med, Dept Biol Chem & Pharmacol, Columbus, OH 43210 USA
[3] Univ Tennessee, Ctr Hlth Sci, Dept Med, Memphis, TN 38163 USA
[4] NIH, Lab Malaria & Vector Res, Bldg 10, Bethesda, MD 20892 USA
来源
ELIFE | 2020年 / 9卷
基金
美国国家卫生研究院;
关键词
N-TERMINAL KINASE; SUPRACHIASMATIC NUCLEUS; ADULT MICE; ACTIVATION; PROTEIN; P75(NTR); SYSTEM; GROWTH; LEADS; CREB;
D O I
10.7554/eLife.52623
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day. Proper circadian alignment of feeding behavior is necessary to prevent metabolic disease, and thus it is imperative that molecular players that maintain neuronal coordination of energy homeostasis are identified. Here, we demonstrate that mice lacking the p75 neurotrophin receptor, p75NTR, decrease their feeding and food anticipatory behavior (FAA) in response to daytime, but not nighttime, restricted feeding. These effects lead to increased weight loss, but do not require p75NTR during development. Instead, p75NTR is required for fasting-induced activation of neurons within the arcuate hypothalamus. Indeed, p75NTR specifically in AgRP neurons is required for FAA in response to daytime restricted feeding. These findings establish p75NTR as a novel regulator gating behavioral response to food scarcity and time-of-day dependence of circadian food anticipation.
引用
收藏
页数:19
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