The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation

被引:9
|
作者
Podyma, Brandon [1 ]
Johnson, Dove-Anna [1 ]
Sipe, Laura [1 ,3 ]
Remcho, Thomas Parks [1 ,4 ]
Battin, Katherine [1 ]
Liu, Yuxi [2 ]
Yoon, Sung Ok [2 ]
Deppmann, Christopher D. [1 ]
Guler, Ali Deniz [1 ]
机构
[1] Univ Virginia, Dept Biol, Charlottesville, VA 22904 USA
[2] Ohio State Univ, Coll Med, Dept Biol Chem & Pharmacol, Columbus, OH 43210 USA
[3] Univ Tennessee, Ctr Hlth Sci, Dept Med, Memphis, TN 38163 USA
[4] NIH, Lab Malaria & Vector Res, Bldg 10, Bethesda, MD 20892 USA
来源
ELIFE | 2020年 / 9卷
基金
美国国家卫生研究院;
关键词
N-TERMINAL KINASE; SUPRACHIASMATIC NUCLEUS; ADULT MICE; ACTIVATION; PROTEIN; P75(NTR); SYSTEM; GROWTH; LEADS; CREB;
D O I
10.7554/eLife.52623
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day. Proper circadian alignment of feeding behavior is necessary to prevent metabolic disease, and thus it is imperative that molecular players that maintain neuronal coordination of energy homeostasis are identified. Here, we demonstrate that mice lacking the p75 neurotrophin receptor, p75NTR, decrease their feeding and food anticipatory behavior (FAA) in response to daytime, but not nighttime, restricted feeding. These effects lead to increased weight loss, but do not require p75NTR during development. Instead, p75NTR is required for fasting-induced activation of neurons within the arcuate hypothalamus. Indeed, p75NTR specifically in AgRP neurons is required for FAA in response to daytime restricted feeding. These findings establish p75NTR as a novel regulator gating behavioral response to food scarcity and time-of-day dependence of circadian food anticipation.
引用
收藏
页数:19
相关论文
共 50 条
  • [1] The p75 neurotrophin receptor
    Underwood, Clare K.
    Coulson, Elizabeth J.
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 40 (09): : 1664 - 1668
  • [2] THE P75 NEUROTROPHIN RECEPTOR
    CHAO, MV
    JOURNAL OF NEUROBIOLOGY, 1994, 25 (11): : 1373 - 1385
  • [3] p75 neurotrophin receptor distribution and transport in cultured neurons
    Formaggio, Elena
    Cantu, Cinzia
    Chiamulera, Christian
    Fumagalli, Guido F.
    NEUROSCIENCE RESEARCH, 2008, 62 (01) : 32 - 42
  • [4] p75 Neurotrophin Receptor and Autism
    Lotta, Louis T., Jr.
    Conrad, Katherine
    Cory-Slechta, Deborah
    Schor, Nina F.
    ANNALS OF NEUROLOGY, 2013, 74 : S84 - S84
  • [5] Neurotrophin signaling through the p75 neurotrophin receptor
    Roux, PP
    Barker, PA
    PROGRESS IN NEUROBIOLOGY, 2002, 67 (03) : 203 - 233
  • [6] CD 271 (p75 neurotrophin receptor)
    Rogers, M-L.
    Beare, A.
    Zola, H.
    Rush, R. A.
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2008, 22 (01): : 1 - 6
  • [7] The p75 neurotrophin receptor and neuronal apoptosis
    Barrett, GL
    PROGRESS IN NEUROBIOLOGY, 2000, 61 (02) : 205 - 229
  • [8] p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure
    Roux, PP
    Colicos, MA
    Barker, PA
    Kennedy, TE
    JOURNAL OF NEUROSCIENCE, 1999, 19 (16): : 6887 - 6896
  • [9] p75(LNTR): an enigmatic neurotrophin receptor
    Muller, Y
    Clos, J
    M S-MEDECINE SCIENCES, 1997, 13 (8-9): : 978 - 986
  • [10] Diverse functions of the p75 neurotrophin receptor
    Yamashita T.
    Fujitani M.
    Hata K.
    Mimura F.
    Yamagishi S.
    Anatomical Science International, 2005, 80 (1) : 37 - 41