Palladium/Xu-Phos Catalyzed Enantioselective Tandem Heck/Cacchi Reaction of Unactivated Alkenes

被引：31
|
作者：
Wu, Yi [1 ]
Xu, Bing [2 ]
Zhao, Guofeng [1 ]
Pan, Zhangjin [1 ]
Zhang, Zhan-Ming [1 ,2 ]
Zhang, Junliang [1 ,2 ]
机构：
[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 3663 N Zhongshan Rd, Shanghai 200062, Peoples R China
[2] Fudan Univ, Dept Chem, 2005 Songhu Rd, Shanghai 200438, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2021年 / 39卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Palladium; Alkenes; Indoles; Asymmetric catalysis; Quaternary stereocenter; ANION CAPTURE PROCESSES; REDUCTIVE HECK REACTION; CYCLIZATION; FUNCTIONALIZATION; CONSTRUCTION; INDOLES; CYCLOADDITION;
D O I：
10.1002/cjoc.202100538
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Main observation and conclusion A highly enantioselective palladium-catalyzed intermolecular tandem Heck/Cacchi reaction of unactivated alkenes with ortho-ethynylanilines was developed, which provides a powerful route to access a broad range of enantioenriched 2,3-dihydrobenzofuran- or indoline-substituted indoles bearing all-carbon quaternary stereocenter of interest in pharmaceutical research. Its salient features include inherent atom- and step-economy, high functional group tolerance, mild conditions, broad structural diversity together with excellent enantioselectivities.
引用
收藏
页码：3255 / 3260
页数：6
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