Enantioselective palladium-catalyzed diarylation of unactivated alkenes

被引：37

作者：

Ju, Baihang ^{[1
]}

Chen, Shigui ^{[1
]}

Kong, Wangqing ^{[1
]}

机构：

[1] Wuhan Univ, Inst Adv Studies IAS, Ctr Precis Synth CPS, Wuhan 430072, Hubei, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 95期

基金：

中国国家自然科学基金;

关键词：

HECK-MATSUDA ARYLATIONS; PINACOL MACROCYCLIZATION CASCADE; ANION PHASE-TRANSFER; CARBONYL-COMPOUNDS; ACYCLIC OLEFINS; DIAZONAMIDE-A; CONSTRUCTION; MORPHINE; DICARBOFUNCTIONALIZATION; DIFUNCTIONALIZATION;

D O I：

10.1039/c9cc07036b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective Pd-catalyzed diarylation of unactivated alkenes between arenediazonium salts and arylboronic acids has been developed. This method provides an efficient route to dihydrobenzofurans with all-carbon quaternary centers in good yields with 88-99% ee. This reaction proceeding under mild and open-flask conditions is compatible with a variety of functional groups, including cyano, ketone, ester, amide, bromine and free hydroxyl groups.

引用

页码：14311 / 14314

页数：4

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