Development and biological evaluation of cerium oxide loaded polycaprolactone dressing on cutaneous wound healing in nursing care

The increasing damage of cutaneous wound infection caused by harmful bacteria is an urgent challenge in nursing care. Herein, a new kind of skin wound dressing is reported by the incorporation of mesoporous CeO2 nanorods into the polycaprolactone (PCL) nanomembrane through an evaporation-induced self-assembly strategy. The nanocomposite membrane was investigated by scanning electron microscopy, X-ray diffraction analysis, and mechanical tensile testing. Also, the as-characterized robust PCL-CeO2 dressing shows high antimicrobial activity against Escherichia coli, and Staphylococcus aureus, strong wound healing effect, and satisfied biocompatibility. This study indicates that the PCL-CeO2 nanocomposite dressing has great potential for cutaneous wound healing application in nursing care. (C) 2020 Elsevier B.V. All rights reserved.