Targeted Gene Repair Facilitated by Peptide Nucleic Acids (PNA)

被引:26
|
作者
Nielsen, Peter E. [1 ,2 ]
机构
[1] Univ Copenhagen, Panum Inst, Fac Hlth Sci, Dept Cellular & Mol Med, DK-2200 Copenhagen N, Denmark
[2] Univ Copenhagen, Fac Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen, Denmark
关键词
DNA recognition; nucleic acids; peptide nucleic acids; recombination; targeted gene repair; ZINC-FINGER NUCLEASES; INTERSTRAND CROSS-LINKS; DOUBLE-DUPLEX INVASION; DOUBLE-STRANDED DNA; GAMMA-PNAS; RECOMBINATION; SPECIFICITY; THALASSEMIA; MUTATION; THERAPY;
D O I
10.1002/cbic.201000346
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:2073 / 2076
页数:4
相关论文
共 50 条
  • [31] Peptide nucleic acids targeted to the amyloid precursor protein
    McMahon, BM
    Stewart, J
    Fauq, A
    Younkin, S
    Younkin, L
    Richelson, E
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2003, 20 (03) : 261 - 265
  • [32] β-PNA: Peptide nucleic acid (PNA) with a chiral center at the β-position of the PNA backbone
    Sugiyama, Toru
    Imamura, Yasutada
    Demizu, Yosuke
    Kurihara, Masaaki
    Takano, Masashi
    Kittaka, Atsushi
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (24) : 7317 - 7320
  • [33] PNA-Pdx: Versatile Peptide Nucleic Acid-Based Detection of Nucleic Acids and SNPs
    Jiang, Wenjun
    Aman, Rashid
    Ali, Zahir
    Rao, Gundra S.
    Mahfouz, Magdy
    ANALYTICAL CHEMISTRY, 2023, 95 (38) : 14209 - 14218
  • [34] Inhibiting gene expression with peptide nucleic acid (PNA)-peptide conjugates that target chromosomal DNA
    Hu, Jiaxin
    Corey, David R.
    BIOCHEMISTRY, 2007, 46 (25) : 7581 - 7589
  • [35] Controlling handedness and DNA binding properties of peptide nucleic acids (PNA) through chirality
    Corradini, Roberto
    Sforza, Stefano
    Tedeschi, Tullia
    Marchelli, Rosangela
    CHIMICA OGGI-CHEMISTRY TODAY, 2007, 25 (05) : 4 - 7
  • [36] SYNTHESIS OF PEPTIDE NUCLEIC-ACIDS (PNA) BY SUBMONOMER SOLID-PHASE SYNTHESIS
    RICHTER, LS
    ZUCKERMANN, RN
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (11) : 1159 - 1162
  • [37] Peptide nucleic acids (PNA) and PNA-DNA chimeras: From high binding affinity towards biological function
    Uhlmann, E
    BIOLOGICAL CHEMISTRY, 1998, 379 (8-9) : 1045 - 1052
  • [38] Olefinic peptide nucleic acids (OPAs):: New aspects of the molecular recognition of DNA by PNA
    Schütz, R
    Cantin, M
    Roberts, C
    Greiner, B
    Uhlmann, E
    Leumann, C
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2000, 39 (07) : 1250 - +
  • [39] Olefinic Peptide Nucleic Acids (OPAs): New Aspects of the Molecular Recognition of DNA by PNA
    Schutz, Rolf
    Cantin, Michel
    Roberts, Christopher
    Greiner, Beate
    Uhlmann, Eugen
    Leumann, Christian
    Angewandte Chemie (International Edition in English), 2000, 39 (07): : 1250 - 1253
  • [40] Allele-specific inhibition of HLA sequencing using peptide nucleic acids (PNA)
    Paul, P
    Jurcago, R
    Schatz, H
    Cook, D
    Ball, E
    HUMAN IMMUNOLOGY, 2005, 66 : S109 - S109