Induction of ER stress protects gastric cancer cells against apoptosis induced by cisplatin and doxorubicin through activation of p38 MAPK

被引：53
|
作者：
Feng, Ruo [1 ]
Zhai, Wen Long [2 ]
Yang, Hai Yan [3 ]
Jin, Hui [1 ]
Zhang, Qin Xian [1 ]
机构：
[1] Zhengzhou Univ, Sch Med, Dept Histol & Embryol, Zhengzhou 450001, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Gen Surg, Zhengzhou 450052, Henan, Peoples R China
[3] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol, Zhengzhou 450051, Henan, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 406卷 / 02期
关键词：
p38; MAPK; ER stress; Gastric cancer; Apopsosis; Cisplatin; Doxorubicin; ENDOPLASMIC-RETICULUM STRESS; CELLULAR-RESPONSE; UP-REGULATION; RESISTANCE; PATHWAY; KINASE; PROLIFERATION; REGULATOR; THERAPY;
D O I：
10.1016/j.bbrc.2011.02.036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the role of endoplasmic reticulum (ER) stress response and p38 MAPIC pathways in the resistance of gastric cancer cells to chemotherapy. Pretreatment of the gastric cancer cells with the ER stress inducer drastically decreased the apoptotic rate induced by cisplatin or doxorubicin. Induction of ER stress also led to the activation of p38. Inhibition of p38 activity abrogated the effects of ER stress-induced resistance to apoptosis induced by cisplatin- and doxorubicin treatment. Thus, ER-stress response in gastric cancer cells causes resistance to cisplatin- and doxorubicin-induced apoptosis, and ER-stress induced chemo-resistance can be overcome by blocking p38 activity. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：299 / 304
页数：6
相关论文
共 50 条
  • [21] Carfilzomib activates ER stress and JNK/p38 MAPK signaling to promote apoptosis in hepatocellular carcinoma cells
    Deng, Yao
    Li, Yujie
    Yang, Mingyue
    Gao, Yang
    Luo, Xuling
    Chen, Hanbin
    Guo, Meng
    Yang, Xuefeng
    Liu, Yongzhang
    He, Jun
    Lu, Bin
    Liu, Naxin
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2024, 56 (05): : 697 - 708
  • [22] p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid
    Liu, Jia
    Wu, Ning
    Ma, Lei-Na
    Zhong, Jia-Teng
    Liu, Ge
    Zheng, Lan-Hong
    Lin, Xiu-Kun
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (11) : 4519 - 4525
  • [23] Xanthohumol induce apoptosis through p38 MAPK signaling pathway in human nasopharyngeal cancer cells
    Lo, M.
    Chen, D.
    LEUKEMIA RESEARCH, 2019, 85 : S70 - S70
  • [24] 14-3-3σ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells
    Kim, In-Kyu
    Park, Sun-Mi
    Cho, Hee Jun
    Baek, Kyoung Eun
    Nam, In-Koo
    Park, Seung-Ho
    Ryu, Ki-Jun
    Ryu, Jinhyun
    Choi, Jungil
    Hong, Soon-Chan
    Kim, Jae Won
    Lee, Chang Won
    Kang, Sang Soo
    Yoo, Jiyun
    ONCOTARGET, 2013, 4 (11) : 2045 - 2056
  • [25] Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation
    Li, Qiang
    Miao, Ziwei
    Wang, Rui
    Yang, Jun
    Zhang, Dianbao
    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2020, 72 (03): : 538 - 545
  • [26] β-Endorphin Induction by Psychological Stress Promotes Leydig Cell Apoptosis through p38 MAPK Pathway in Male Rats
    Xiong, Xiaofan
    Zhang, Lingyu
    Fan, Meiyang
    Han, Lin
    Wu, Qiuhua
    Liu, Siyuan
    Miao, Jiyu
    Liu, Liying
    Wang, Xiaofei
    Guo, Bo
    Tong, Dongdong
    Ni, Lei
    Yang, Juan
    Huang, Chen
    CELLS, 2019, 8 (10)
  • [27] Glutamate-induced p38 MAPK activation in Bergmann glial cells
    Zepeda, R. C.
    Hernandez-Kelly, L. C.
    Gonzalez-Mejia, M. E.
    Castelan, F.
    Ortega, A.
    JOURNAL OF NEUROCHEMISTRY, 2007, 102 : 108 - 109
  • [28] Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK
    Zhang, H
    Vollmer, M
    De Geyter, M
    Dürrenberger, M
    De Geyter, C
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2005, 26 (06) : 1575 - 1580
  • [29] Anastasis confers ovarian cancer cells increased malignancy through elevated p38 MAPK activation
    Lili Sun
    Chen Yao
    Xiaojiao Li
    Yuxing Wang
    Ru Wang
    Molin Wang
    Qiao Liu
    Denise J. Montell
    Changshun Shao
    Yaoqin Gong
    Gongping Sun
    Cell Death & Differentiation, 2023, 30 : 809 - 824
  • [30] Anastasis confers ovarian cancer cells increased malignancy through elevated p38 MAPK activation
    Sun, Lili
    Yao, Chen
    Li, Xiaojiao
    Wang, Yuxing
    Wang, Ru
    Wang, Molin
    Liu, Qiao
    Montell, Denise J.
    Shao, Changshun
    Gong, Yaoqin
    Sun, Gongping
    CELL DEATH AND DIFFERENTIATION, 2023, 30 (03): : 809 - 824
12345