Improved SERS Nanoparticles for Direct Detection of Circulating Tumor Cells in the Blood

被引：134
|
作者：
Wu, Xiaoxia [1 ,2 ,3 ]
Luo, Liqiang [1 ]
Yang, Sugeun [4 ]
Ma, Xuehua [2 ,3 ]
Li, Yonglong [2 ,3 ]
Dong, Chen [2 ,3 ]
Tian, Yuchen [2 ,3 ]
Zhang, Ling'e [2 ,3 ]
Shen, Zheyu [2 ,3 ]
Wu, Aiguo [2 ,3 ]
机构：
[1] Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China
[2] Chinese Acad Sci, Div Funct Mat & Nano Devices, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China
[3] Chinese Acad Sci, Key Lab Magnet Mat & Devices, Ningbo 315201, Zhejiang, Peoples R China
[4] Inha Univ, Sch Med, Dept New Drug Dev, Inchon 400712, South Korea
来源：
ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 18期
基金：
中国国家自然科学基金; 新加坡国家研究基金会;
关键词：
surface-enhanced Raman scattering; circulating tumor cells; direct detection; blood; excellent specificity; high sensitivity; SURFACE-ENHANCED RAMAN; ALPHA FRA EXPRESSION; FOLATE-RECEPTOR; GOLD NANOPARTICLES; CANCER; SCATTERING; ANTIAGGREGATION; NANOMEDICINE; DIAGNOSIS;
D O I：
10.1021/acsami.5b02276
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The detection of circulating tumor cells (CTCs) in the blood of cancer patients is crucial for early can(er diagnosis, cancer prognosis, evaluation of the treatment effect of chemotherapy drugs, and choice of cancer treatment options. In this study, we propose new surface-enhanced Raman scattering (SERS) nanoparticles for the direct detection of CTCs in the blood. Under the optimized experimental conditions, our SERS nanoparticles exhibit satisfying performances for the direct detection of cancer cells in the rabbit blood. A good linear relationship is obtained between the SERS intensity and the concentration of cancer cells in the range of 5-500 cells/mL (R-2 = 0.9935), which demonstrates that the SERS nanoparticles can be used for the quantitative analysis of cancer cells in the blood and the limit of detection is 5 cells/mL, which is lowest compared with the reported values. The SERS nanoparticles also have an excellent specificity for the detection of cancer cells in the rabbit blood. The above results reinforce that our SERS nanoparticles can be used for the direct detection of CTCs in the blood with excellent specificity and high sensitivity.
引用
收藏
页码：9965 / 9971
页数：7
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