Expert Opinion on Managing Chronic HCV Infection in Patients with Type 2 Diabetes Mellitus

被引：10
|
作者：
Adinolfi, Luigi Elio [1 ]
Jacobson, Ira [2 ]
Bondin, Mark [3 ]
Cacoub, Patrice [4 ,5 ,6 ,7 ,8 ]
机构：
[1] Univ Campania Luigi Vanvitelli, Dept Med Surg Neurol Metab & Geriatr Sci, Naples, Italy
[2] NYU Langone Hlth, New York, NY USA
[3] AbbVie Inc, Chicago, IL USA
[4] UPMC Univ Paris 06, Sorbonne Univ, UMR 7211, Paris, France
[5] UPMC Univ Paris 06, Sorbonne Univ, Inflammat Immunopathol Biotherapy Dept DHU i2B, Paris, France
[6] INSERM, UMR S 959, Paris, France
[7] CNRS, FRE3632, Paris, France
[8] Grp Hosp Pitie Salpetriere, AP HP, Dept Internal Med & Clin Immunol, Paris, France
来源：
ANTIVIRAL THERAPY | 2018年 / 23卷
关键词：
HEPATITIS-C VIRUS; SUSTAINED VIROLOGICAL RESPONSE; INSULIN-RESISTANCE; HEPATOCELLULAR-CARCINOMA; INCREASED RISK; EXTRAHEPATIC MANIFESTATIONS; GENOTYPE DISTRIBUTION; ANTIVIRAL TREATMENT; ADVANCED FIBROSIS; GLYCEMIC CONTROL;
D O I：
10.3851/IMP3255
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Type 2 diabetes mellitus (T2DM) has been identified as an extrahepatic manifestation of chronic HCV infection. Conversely, in the context of chronic HCV infection, T2DM can accelerate the course of HCV-induced liver disease leading to increased risk of fibrosis, cirrhosis and hepa-tocellular carcinoma. The presence of T2DM negatively impacts the efficacy of interferon-based antiviral therapy, but real-world data with high-efficacy direct-acting antiviral therapies suggest high viral clearance rates in T2DM patients. In HCV-infected individuals, viral eradication is associated with a reduced risk of de novo T2DM in non-diabetic patients and beneficial metabolic changes in patients with T2DM, highlighting the importance of antiviral treatment and physician awareness of this association.
引用
收藏
页码：11 / 21
页数：11
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