Evaluation of Applicability of Aminodiphosphonic Acids for the Development of Bone-Seeking 68Ga-Radiopharmaceuticals

被引：2
|
作者：
Mitrofanov, Iu. A. [1 ]
Maruk, A. Ya. [1 ,2 ]
Larenkov, A. A. [1 ,3 ]
Kodina, G. E. [1 ]
Lunev, A. S. [1 ]
Luneva, K. A. [1 ]
Klementyeva, O. E. [1 ]
Tsebrikova, G. S. [2 ]
Baulin, V. E. [2 ,4 ]
Ragulin, V. V. [4 ]
Tsivadze, A. Yu. [2 ]
机构：
[1] Fed Med Biol Agcy, Burnasyan Fed Med Biophys Ctr, Russian State Res Ctr, Moscow 123098, Russia
[2] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia
[3] Lomonosov Moscow State Univ, Moscow 199991, Russia
[4] Russian Acad Sci, Inst Physiol Act Subst, Chernogolovka 142432, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 03期
基金：
俄罗斯科学基金会; 俄罗斯基础研究基金会;
关键词：
Ga-68; diphosphonates; aminodiphosphonic acids; osteotropic radiopharmaceuticals; hydroxyapatite; OPTIMIZED PRODUCTION; IN-VITRO; GA-68; BISPHOSPHONATES; MECHANISMS;
D O I：
10.1134/S107036322003010X
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The binding of Ga-68 to two organic ligands containing aminodiphosphonic groups (1,7-diamino-4-oxaheptane-1,1,7,7-tetraphosphonic and 1,7-diamino-4-hydroxycarbonylheptane-1,1,7,7-tetraphosphonic acids) has been examined. The stability and osteotropic potential of the labeled compounds have been evaluated.
引用
收藏
页码：390 / 397
页数：8
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