Evaluation of Applicability of Aminodiphosphonic Acids for the Development of Bone-Seeking 68Ga-Radiopharmaceuticals

被引：2

作者：

Mitrofanov, Iu. A. ^{[1
]}

Maruk, A. Ya. ^{[1
,2
]}

Larenkov, A. A. ^{[1
,3
]}

Kodina, G. E. ^{[1
]}

Lunev, A. S. ^{[1
]}

Luneva, K. A. ^{[1
]}

Klementyeva, O. E. ^{[1
]}

Tsebrikova, G. S. ^{[2
]}

Baulin, V. E. ^{[2
,4
]}

Ragulin, V. V. ^{[4
]}

Tsivadze, A. Yu. ^{[2
]}

机构：

[1] Fed Med Biol Agcy, Burnasyan Fed Med Biophys Ctr, Russian State Res Ctr, Moscow 123098, Russia

[2] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia

[3] Lomonosov Moscow State Univ, Moscow 199991, Russia

[4] Russian Acad Sci, Inst Physiol Act Subst, Chernogolovka 142432, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 03期

基金：

俄罗斯科学基金会; 俄罗斯基础研究基金会;

关键词：

Ga-68; diphosphonates; aminodiphosphonic acids; osteotropic radiopharmaceuticals; hydroxyapatite; OPTIMIZED PRODUCTION; IN-VITRO; GA-68; BISPHOSPHONATES; MECHANISMS;

D O I：

10.1134/S107036322003010X

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The binding of Ga-68 to two organic ligands containing aminodiphosphonic groups (1,7-diamino-4-oxaheptane-1,1,7,7-tetraphosphonic and 1,7-diamino-4-hydroxycarbonylheptane-1,1,7,7-tetraphosphonic acids) has been examined. The stability and osteotropic potential of the labeled compounds have been evaluated.

引用

页码：390 / 397

页数：8

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