Objective: To evaluate surgical outcome and long-term follow-up of conservative laparoscopic management of urinary tract endometriosis (UTE). Design: Prospective study. Setting: Tertiary-care university hospital. Patient(s): Women with laparoscopic diagnosis and histologic confirmation of urinary bladder or ureteral endometriosis who agreed to undergo long-term follow-up after laparoscopic management. Intervention(s): (1) Laparoscopic partial cystectomy for bladder endometriosis. (2) Uretric endometriosis laparoscopically managed by: uretrolysis only; segmental ureterectomy and terminoterminal anastomosis; or segmental ureterectomy and uretrocystoneostomy. Main Outcome Measure(s): Variables assessed were: preoperative findings, operative details (type and site of UTE, type of intervention, perioperative complications), and long-term follow-up (persistence/recurrence of preoperative urinary symptoms, if present, and anatomic relapse of the disease). Result(s): Mean operating time was 152.8 +/- 41.7 minutes. Mean drop in hemoglobin was 1.9 +/- 1.6 g/dL. Average hospital stay was 6 days. After surgery, 11 women had fever >38 degrees C and four presented transient urinary retention. During a follow-up period of 36 months, endometriosis recurred in eight patients with no evidence of bladder or ureteral reinvolvement, and there was a significant reduction in the mean score of dysuria and suprapubic pain maintained during the whole follow-up period. Conclusion(s): Results of long-term follow-up demonstrate significant reduction in preoperative symptoms with no anatomic relapse (Fertil Steril (R) 2010; 94: 856-61. (c) 2010 by American Society for Reproductive Medicine.)