Activity of Antimicrobial Combinations against KPC-2-Producing Klebsiella pneumoniae in a Rat Model and Time-Kill Assay

被引：28

作者：

Michelon Toledo, Paula Virginia ^{[1
,2
]}

Aranha Junior, Ayrton Alves ^{[2
,3
]}

Arend, Lavinia Nery ^{[4
]}

Ribeiro, Vanessa ^{[5
]}

Zavascki, Alexandre Prehn ^{[5
]}

Tuon, Felipe Francisco ^{[1
,6
]}

机构：

[1] Univ Fed Parana, Internal Med Postgrad Training, BR-80060000 Curitiba, Parana, Brazil

[2] Univ Estadual Ponta Grossa, Dept Med, Ponta Grossa, Brazil

[3] Univ Fed Parana, Dept Anat, BR-80060000 Curitiba, Parana, Brazil

[4] Bacteriol Sect, Lab Cent Saude Publ Estado LACEN PR, Curitiba, Parana, Brazil

[5] Hosp Clin Porto Alegre, Infect Dis Serv, Porto Alegre, RS, Brazil

[6] Hosp Univ Evangel Curitiba, Div Infect & Parasit Dis, Curitiba, Parana, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 07期

关键词：

POLYMYXIN-B; TIGECYCLINE; INFECTIONS; MEROPENEM; MORTALITY; EFFICACY; GLYCYLCYCLINE; GENTAMICIN; PREDICTORS; BACTEREMIA;

D O I：

10.1128/AAC.00323-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study evaluated the efficacy of tigecycline (TIG), polymyxin B (PMB), and meropenem (MER) in 80 rats challenged with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae infection. A time-kill assay was performed with the same strain. Triple therapy and PMB + TIG were synergistic, promoted 100% survival, and produced negative peritoneal cultures, while MER + TIG showed lower survival and higher culture positivity than other regimens (P = 0.018) and was antagonistic. In vivo and in vitro studies showed that combined regimens, except MER + TIG, were more effective than monotherapies for this KPC-producing strain.

引用

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页码：4301 / 4304

页数：4

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